Erk in kidney diseases.
Erk in kidney diseases.
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DOI：
10.1155/2011/768512
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Kasinath BS
中科院分区：
文献类型：
--
作者：
Feliers D;Kasinath BS
急性或慢性肾损伤是由各种损伤和病理条件引起的，并伴有代偿性修复机制的激活。损伤和修复机制均由循环因子启动，其细胞效应由活化选择性信号转导途径介导。在这些过程中，两个主要的信号转导途径被激活，磷脂酰肌醇3′激酶（PI-3 K）/雷帕霉素的哺乳动物靶标（mTOR）和促分裂原活化蛋白激酶（MAPK）级联。本文将重点介绍后者，更具体地说是细胞外信号调节激酶（ERK）级联在肾损伤和修复中的作用。
Acute or chronic kidney injury results from various insults and pathological conditions, and is accompanied by activation of compensatory repair mechanisms. Both insults and repair mechanisms are initiated by circulating factors, whose cellular effects are mediated by activation selective signal transduction pathways. Two main signal transduction pathways are activated during these processes, the phosphatidylinositol 3′ kinase (PI-3K)/mammalian target of rapamycin (mTOR) and the mitogen-activated protein kinase (MAPK) cascades. This review will focus on the latter, and more specifically on the role of extracellular signal-regulated kinase (ERK) cascade in kidney injury and repair.