Influenza at the animal-human interface: a review of the literature for virological evidence of human infection with swine or avian influenza viruses other than A(H5N1)
Influenza at the animal-human interface: a review of the literature for virological evidence of human infection with swine or avian influenza viruses other than A(H5N1)
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DOI：
10.2807/1560-7917.es2014.19.18.20793
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发表时间：
2014-05-08
期刊：
影响因子：
19
通讯作者：
Koopmans, M.
中科院分区：
文献类型：
--
作者：
Freidl, G. S.;Meijer, A.;Koopmans, M.
引发人类感染动物流感病毒并演变为大流行的因素知之甚少。在一个开发基于证据的动物流感病毒风险评估框架的项目中，我们对文献进行了回顾，以寻找通过使用的诊断方法证明人类感染动物流感病毒的证据。这篇涵盖Medline、Embase、SciSearch和CabAbstract的综述共产生6955篇文章，我们保留了89篇；对于甲型H5N1流感和甲型H7N9流感，使用了世界卫生组织的官方病例统计。通过扫描参考文献列表，纳入了另外30项研究。在这里，我们提出了有病毒学证据的确诊感染的结果。我们发现了1419例自然感染的人类病例，其中648例与禽流感病毒(H5N1)有关，375例与其他禽流感病毒亚型有关，396例与猪流感病毒(SIV)有关。自然感染禽流感病毒的人类病例跨越血凝素亚型H5、H6、H7、H9和H10。SIV病例与北美和欧亚SIV谱系及其各种重组体的H1和H3亚型地方性SIV有关。直接接触禽类或猪是有关于接触情况的现有信息的病例最有可能的感染源。
Factors that trigger human infection with animal influenza virus progressing into a pandemic are poorly understood. Within a project developing an evidence-based risk assessment framework for influenza viruses in animals, we conducted a review of the literature for evidence of human infection with animal influenza viruses by diagnostic methods used. The review covering Medline, Embase, SciSearch and CabAbstracts yielded 6,955 articles, of which we retained 89; for influenza A(H5N1) and A(H7N9), the official case counts of the World Health Organization were used. An additional 30 studies were included by scanning the reference lists. Here, we present the findings for confirmed infections with virological evidence. We found reports of 1,419 naturally infected human cases, of which 648 were associated with avian influenza virus (AIV) A(H5N1), 375 with other AIV subtypes, and 396 with swine influenza virus (SIV). Human cases naturally infected with AIV spanned haemagglutinin subtypes H5, H6, H7, H9 and H10. SIV cases were associated with endemic SIV of H1 and H3 subtype descending from North American and Eurasian SIV lineages and various reassortants thereof. Direct exposure to birds or swine was the most likely source of infection for the cases with available information on exposure.