Avolition in schizophrenia is associated with reduced willingness to expend effort for reward on a Progressive Ratio task.
Avolition in schizophrenia is associated with reduced willingness to expend effort for reward on a Progressive Ratio task.
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DOI：
10.1016/j.schres.2015.12.006
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发表时间：
2016-01
影响因子：
4.5
通讯作者：
Frost KH
中科院分区：
文献类型：
--
作者：
Strauss GP;Whearty KM;Morra LF;Sullivan SK;Ossenfort KL;Frost KH
目前的研究调查了努力成本计算是否与精神分裂症(SZ)的阴性症状有关。参与者包括被诊断为SZ的门诊患者(n=27)和人口统计学上匹配的健康对照组(n=32)，他们完成了一项累进比率任务，需要逐渐增加体力以获得金钱奖励。断点是参与者不再愿意为某个回报价值付出努力的点，它被作为努力成本计算的指标进行了审查。在累进比率任务中，低、中、高价值奖励的断点没有组别差异。然而，在SZ患者中，较低的断点得分与更严重的撕裂和快感缺乏症状相关。研究结果提供了进一步的证据，表明努力-成本计算受损与深圳的动机异常有关。
The current study examined whether effort-cost computation was associated with negative symptoms of schizophrenia (SZ). Participants included outpatients diagnosed with SZ (n = 27) and demographically matched healthy controls (n = 32) who completed a Progressive Ratio Task that required incrementally greater amounts of physical effort to obtain monetary reward. Breakpoint, the point at which participants were no longer willing to exert effort for a certain reward value, was examined as an index of effort-cost computation. There were no group differences in breakpoint for low, medium, or high value rewards on the Progressive Ratio Task. However, lower breakpoint scores were associated with greater severity of avolition and anhedonia symptoms in SZ patients. Findings provide further evidence that impaired effort-cost computation is linked to motivational abnormalities in SZ.