6-Hydroxydopamine induces degenerative changes in innervation of the rat pituitary gland.
6-Hydroxydopamine induces degenerative changes in innervation of the rat pituitary gland.
复制标题
6-Hydroxydopamine 诱导大鼠垂体神经支配的退行性变化。
DOI：
10.1016/0304-3940(85)90039-4
复制
发表时间：
1985
影响因子：
2.5
通讯作者：
Comunas,F
中科院分区：
文献类型：
--
作者：
Saland,LC;Comunas,F
通过外周注射给成年雄性大鼠施用 6-羟基多巴胺，会诱导垂体中叶神经末梢神经细胞的退行性变化。其他动物接受了 5-羟基多巴胺治疗，产生了包含具有电子密集中心的囊泡的神经轮廓图像，表明假儿茶酚胺 (CA) 神经递质的摄取。内分泌细胞显示出合成室和分泌室激活的细胞学证据。超微结构观察表明，阿片黑皮素细胞的神经支配对 CA 特异性神经毒素敏感，并强化了含 CA 纤维在中叶神经调节中发挥作用的假设。
Administration of 6-hydroxydopamine to adult male rats by peripheral injections induces degenerative changes in nerve terminals innervating cells of the pituitary intermediate lobe. Additional animals were treated with 5-hydroxydopamine, which produced images of nerve profiles containing vesicles with electron-dense centers, indicative of uptake of the false catecholamine (CA) neurotransmitter. Endocrine cells showed cytologic evidence of activation of synthetic and secretory compartments. The ultrastructural observations suggest that innervation to opiomelanocortin cells is sensitive to a CA-specific neurotoxin and strengthens the hypothesis that CA-containing fibers play a role in intermediate lobe neuroregulation.