Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease.
Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease.
复制标题
肝脂肪酶多态性与迟发性阿尔茨海默氏病缺乏关联。
DOI：
10.1016/j.neurobiolaging.2006.11.015
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发表时间：
2008
影响因子：
4.2
通讯作者：
Estus,Steven
中科院分区：
文献类型：
--
作者：
Zhu,Haiyan;Taylor,JennieW;Bennett,DavidA;Younkin,StevenG;Estus,Steven
Several polymorphisms in hepatic lipase (LIPC) are similar to apoE4 because they associate with cholesterol concentrations and, for rs6084, coronary artery disease (CAD). Since apoE4 is also a primary genetic risk factor for late-onset Alzheimer’s disease (LOAD), LIPC single nucleotide polymorphisms (SNP)s represent excellent candidates for LOAD association studies. Because this issue has not been addressed previously, we evaluated LIPC SNP association with LOAD. In a population from the Religious Orders Study (ROS), rs6084 was nominally associated with LOAD odds (p=0.015 by χ2 test). However, this association was not confirmed in two subsequent series based at the University of Kentucky (UKY, p=0.15) or the Mayo Clinic in Jacksonville (MCJ, p=0.97). Hence, rs6084 is not consistently associated with LOAD.
