In-vivo measurements of human brain tissue conductivity using focal electrical current injection through intracerebral multicontact electrodes
In-vivo measurements of human brain tissue conductivity using focal electrical current injection through intracerebral multicontact electrodes
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DOI：
10.1002/hbm.23431
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发表时间：
2017-02-01
影响因子：
4.8
通讯作者：
Maillard, Louis G.
中科院分区：
文献类型：
--
作者：
Koessler, Laurent;Colnat-Coulbois, Sophie;Maillard, Louis G.
使用通过脑内多触点电极注入的局灶电流，在体温下进行人脑组织电导率的体内测量。分析了15名癫痫患者（年龄：28 ± 10岁）使用射频发生器（50 kHz电流注入）进行的总计1，421次测量。使用局部组织环境的神经成像分析和脑内EEG记录，将每个接触对分类为健康（灰质，n=696;白色物质，n=530）或病理（致痫区，n=195）组织。使用基于电导率估计值的数值模拟获得脑组织电导率，该电导率估计值考虑了接触对（边长为13 mm的立方体）周围局部脑体积中的电流。灰质的电导率值为0.26 S/m，白色物质的电导率值为0.17 S/m。健康灰质和白色物质的中值阻抗具有统计学差异（P
In-vivo measurements of human brain tissue conductivity at body temperature were conducted using focal electrical currents injected through intracerebral multicontact electrodes. A total of 1,421 measurements in 15 epileptic patients (age: 28 +/- 10) using a radiofrequency generator (50 kHz current injection) were analyzed. Each contact pair was classified as being from healthy (gray matter, n=696; white matter, n=530) or pathological (epileptogenic zone, n=195) tissue using neuroimaging analysis of the local tissue environment and intracerebral EEG recordings. Brain tissue conductivities were obtained using numerical simulations based on conductivity estimates that accounted for the current flow in the local brain volume around the contact pairs (a cube with a side length of 13 mm). Conductivity values were 0.26 S/m for gray matter and 0.17 S/m for white matter. Healthy gray and white matter had statistically different median impedances (P