Multiple sclerosis in Hispanics: a study of clinical disease expression
Multiple sclerosis in Hispanics: a study of clinical disease expression
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DOI：
10.1177/1352458511403025
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发表时间：
2011-08-01
影响因子：
5.8
通讯作者：
Islam, T.
中科院分区：
文献类型：
--
作者：
Amezcua, L.;Lund, B. T.;Islam, T.
背景：在美国，西班牙裔多发性硬化症（MS）患者的定义并不明确。目的：比较南加州西班牙裔白人（HW）与非西班牙裔白人（NHW）多发性硬化症的临床特征。方法：我们进行了一项医疗图表回顾，以确定在我们机构治疗的1年内所有HW合并MS病例（n = 125）。我们还确定了在这些诊所治疗的NHW合并MS的病例（100 NHW）。对所有HW患者进行访谈以确定其祖先，包括详细的迁移史。疾病进展通过活动能力评估，并定义为扩展残疾状态量表（EDSS）评分>= 6。结果：与NHW相比，HW更有可能出现复发缓解型MS，发病年龄更年轻（28.4±0.97岁），表现为视神经炎和横切性脊髓炎。然而，总体的活动功能障碍在高福利组和低福利组之间没有差异。15岁移民美国与HW致残风险增加有关。结论：生活在美国的高净值人群与非高净值人群相比，可能在更早的年龄有发生MS的风险。迁移历史可以在MS的HW管理中发挥重要作用。
Background: Hispanics living with multiple sclerosis (MS) in the United States are not well defined.Objective: To describe the clinical characteristics of MS among Hispanic Whites (HW) in Southern California with those of non-Hispanic Whites (NHW).Methods: We performed a medical chart review to identify all cases of HW with MS (n = 125) who were treated at our institution during a 1-year period. We also identified cases of NHW with MS (100 NHW) treated at those clinics. All HW patients were interviewed to ascertain ancestry including detailed migration history. Disease progression was assessed by ambulatory disability and defined as Expanded Disability Status Scale (EDSS) score >= 6.Results: Compared with NHW, HW were more likely to have a relapsing-remitting form of MS and a younger age of onset (28.4 +/- 0.97 years) with presenting symptoms of optic neuritis and transverse myelitis. However, overall ambulatory disability did not differ between HW and NHW. Migration to the US at age >15 years was associated with increased risk of disability in HW.Conclusions: HW living in the USA may be at risk of developing MS at an earlier age compared with NHW. Migration history can play an important role in the management of HW with MS.