Rote of nonimmune IgG bound to PfEMP1 in placental malaria
Rote of nonimmune IgG bound to PfEMP1 in placental malaria
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DOI：
10.1126/science.1062891
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发表时间：
2001-09-14
期刊：
影响因子：
56.9
通讯作者：
Wahlgren, M
中科院分区：
文献类型：
--
作者：
Flick, K;Scholander, C;Wahlgren, M
妊娠期间感染恶性疟原虫会导致胎盘中寄生的红细胞(受感染的红细胞，IES)聚集。感染人胎盘的恶性疟原虫分离株的IES能结合免疫球蛋白G(Ig G)。克隆的恶性疟原虫免疫球蛋白结合株大量黏附于胎盘合体滋养层细胞，其黏附模式与自然感染相似。黏附可被免疫球蛋白结合蛋白抑制，但不能被糖胺多聚糖或硫酸软骨素A或透明质酸的酶消化所抑制。与恶性疟原虫红细胞膜蛋白1(PfEMP1)的Duffy结合样区结合的正常非免疫性免疫球蛋白可能在IE表面作为新生儿胎盘Fc受体的桥梁。
Infections with Plasmodium falciparum during pregnancy lead to the accumulation of parasitized red blood cells (infected erythrocytes, IEs) in the placenta. IEs of A falciparum isolates that infect the human placenta were found to bind immunoglobulin G (IgG). A strain of P. falciparum cloned for IgG binding adhered massively to placental syncytiotrophoblasts in a pattern similar to that of natural infections. Adherence was inhibited by IgG-binding proteins, but not by glycosaminoglycans or enzymatic digestion of chondroitin sulfate A or hyaluronic acid. Normal, nonimmune IgG that is bound to a duffy binding-like domain beta of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) might at the IE surface act as a bridge to neonatal Fc receptors of the placenta.