Induction of senescence by adenosine suppressing the growth of lung cancer cells.
Induction of senescence by adenosine suppressing the growth of lung cancer cells.
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DOI：
10.1016/j.bbrc.2013.09.030
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发表时间：
2013-10
影响因子：
3.1
通讯作者：
Dongqin Yang;Junyao Song;Lijun Wu;Yunfang Ma;Chunhua Song;S. Dovat;T. Nishizaki;Jie Liu
中科院分区：
文献类型：
--
作者：
Dongqin Yang;Junyao Song;Lijun Wu;Yunfang Ma;Chunhua Song;S. Dovat;T. Nishizaki;Jie Liu
Extracellular adenosine is well reported to suppress tumor growth by induction of apoptosis. However, in this study we found that adenosine treatment results in cellular senescence in A549 lung cancer cells bothin vitroandin vivo; adenosine induces cell cycle arrest and senescence in a p53/p21 dependent manner; adenosine elevates the level of phosphor-γH2AX, pCHK2 and pBRCA1, the markers for prolonged DNA damage response which are likely responsible for initiating the cellular senescence. Our study first demonstrates that adenosine suppresses growth of cancer cells by inducing senescence and provides additional evidence that adenosine could act as an effective anticancer agent for targeted cancer therapy.
