Regulation of primary response genes.
Regulation of primary response genes.
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DOI：
10.1016/j.molcel.2011.09.014
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发表时间：
2011-11-04
期刊：
影响因子：
16
通讯作者：
Roy AL
中科院分区：
文献类型：
--
作者：
Fowler T;Sen R;Roy AL
初级应答基因（Primary response genes, PRGs）是一组被诱导响应细胞外部和细胞内部信号的基因，它们的表达不需要从头合成蛋白质。这些信号应答基因转录波中的“第一响应者”在广泛的生物反应中发挥关键作用，包括神经元存活和可塑性、心脏应激反应、先天和适应性免疫反应、葡萄糖代谢和癌基因转化。在这里，我们汇集了最近的进展和我们目前对PRGs的信号诱导转录和表观遗传调控的理解。
Primary response genes (PRGs) are a set of genes that are induced in response to both cell-extrinsic and cell-intrinsic signals and do not require de novo protein synthesis for their expression. These 'first responders' in the waves of transcription of signal responsive genes play pivotal roles in a wide rage of biological responses, including neuronal survival and plasticity, cardiac stress response, innate and adaptive immune responses, glucose metabolism and oncogeneic transformation. Here we bring together recent advances and our current understanding of the signal-induced transcriptional and epigenetic regulation of PRGs.