The roles of tumor-derived exosomes in cancer pathogenesis.
The roles of tumor-derived exosomes in cancer pathogenesis.
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DOI：
10.1155/2011/842849
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发表时间：
2011
影响因子：
--
通讯作者：
Robbins PD
中科院分区：
文献类型：
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作者：
Yang C;Robbins PD
外泌体是内体衍生的30-100 nm小膜囊泡，由大多数细胞类型（包括肿瘤细胞）释放。它们富含来自亲本细胞的蛋白质和核酸的选择性库，并且被认为积极参与赋予细胞间信号。肿瘤来源的外泌体已被视为可用于诱导抗肿瘤免疫应答的肿瘤抗原的来源。然而，肿瘤来源的外泌体也被发现具有免疫抑制特性，并且能够促进肿瘤生长、转移和耐药性的发展。肿瘤来源的外泌体的这些不同作用有助于癌症的发病机制。本文将讨论肿瘤源性外泌体在癌症发病机制，治疗和诊断中的作用。
Exosomes are endosome-derived, 30–100 nm small membrane vesicles released by most cell types including tumor cells. They are enriched in a selective repertoire of proteins and nucleic acids from parental cells and are thought to be actively involved in conferring intercellular signals. Tumor-derived exosomes have been viewed as a source of tumor antigens that can be used to induce antitumor immune responses. However, tumor-derived exosomes also have been found to possess immunosuppressive properties and are able to facilitate tumor growth, metastasis, and the development of drug resistance. These different effects of tumor-derived exosomes contribute to the pathogenesis of cancer. This review will discuss the roles of tumor-derived exosomes in cancer pathogenesis, therapy, and diagnostics.