CD8α+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleen
CD8α+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleen
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DOI：
10.1016/j.immuni.2006.07.017
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发表时间：
2006-10-01
期刊：
影响因子：
32.4
通讯作者：
Busch, Dirk H.
中科院分区：
文献类型：
--
作者：
Neuenhahn, Michael;Kerksiek, Kristen M.;Busch, Dirk H.
树突状细胞（DCs）除了在先天免疫和适应性免疫之间起桥梁作用外，还可能有助于抵抗感染。在这里，我们分析了在单核细胞增多性李斯特菌感染过程中，这些细胞进行系统的体内耗竭的DC的作用。我们发现CD8 α（+）DCs对L.单核细胞增多症在脾脏中扩散和增殖。高效、快速地吸收L.通过CD8 α（+）DC对单核细胞增生的抑制需要小的GTCRac 1，并且是该DC亚群在将颗粒过滤出血液中的一般特征。因此，CD8 α（+）DC似乎在细菌有效进入脾脏中起重要作用，这与随后的免疫应答相关。
In addition to their bridging function between innate and adaptive immunity, dendritic cells (DCs) may also contribute to primary resistance against infection. Here we analyzed the role of DCs during infection with Listeria monocytogenes by performing systemic in vivo depletion of these cells. We showed that CD8 alpha(+) DCs were crucial for L. monocytogenes spreading and proliferation in the spleen. Efficient and rapid uptake of L. monocytogenes by CD8 alpha(+) DCs required the small GTPase Rac1 and is a general characteristic of this DC subpopulation in filtering particles out of the blood. Thus, CD8 alpha(+) DCs appear to play an important role for efficient bacterial entry into the spleen, which is of relevance for subsequent immune responses.