Increasing health equity through biospecimen research: Identification of factors that influence willingness of Native Americans to donate biospecimens.
Increasing health equity through biospecimen research: Identification of factors that influence willingness of Native Americans to donate biospecimens.
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DOI：
10.1016/j.pmedr.2021.101311
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发表时间：
2021-03
影响因子：
2.8
通讯作者：
Buchwald DS
中科院分区：
文献类型：
--
作者：
Sinclair KA;Muller C;Noonan C;Booth-LaForce C;Buchwald DS
捐献生物标本的意愿与过去的捐献有关。对研究人员如何使用和储存生物样品的信任影响了意愿。对研究开发和精神信仰的恐惧降低了他们的意愿。如果生物库由美洲原住民组织运营，意愿就会增加。如果生物库由联邦政府运营，意愿就会降低。美国印第安人和阿拉斯加原住民(AI/AN)在生物医学研究中的代表性不足，特别是在生物医学研究中，但很少有人进行研究来评估AI/AN对生物医学捐赠的态度。2016年在华盛顿州西雅图从278名AI/AN人那里收集了调查数据，以评估捐赠的一般意愿、与意愿相关的背景特征，以及会增加或降低捐赠生物标本意愿的情况。不到一半(43%)的参与者愿意捐献。总体意愿与过去的捐赠以及对研究人员如何使用和存储生物标本的信任有关。然而，愿意为癌症研究捐款的比例为76%。对研究开发和精神信仰的恐惧降低了他们的意愿。在那些通常不愿捐赠的人中，如果生物库由美洲原住民组织运营，如果参与者或家庭成员患有癌症并且这是正在研究的疾病，如果社区参与开发、审查和批准研究，如果研究人员的专业知识已知，他们的意愿就会增加。在那些有意愿的人中，如果他们从未听说过这个研究机构，如果生物库是由联邦政府运营的，他们的意愿就会降低。人工智能/AN人参与生物库倡议对于解决健康不平等问题、改善AI/AN人的健康、实现个性化医学目标以及解决当前临床和生物医学研究有限的推广能力至关重要。这些结果突出了可以开发干预措施的领域，以增加用于研究的人工智能/人工智能的生物检疫捐赠，最终目标是减少健康差距。
Willingness to donate biospecimens was related to past donation. Trust in how researchers would use and store biospecimens influenced willingness. Fear of research exploitation and spiritual beliefs decreased willingness. Willingness increased if the biobank was run by a Native American organization. Willingness decreased if the biobank was run by the federal government. American Indian and Alaska Native (AI/AN) people are underrepresented in biomedical research, particularly in biospecimen research, yet little research has been conducted to assess AI/AN attitudes about biospecimen donation. Survey data were collected from 278 AI/AN people in Seattle, Washington in 2016 to assess general willingness to donate, background characteristics related to willingness, and circumstances that would increase or decrease willingness to donate biospecimens. Less than half (43%) of participants were willing to donate. General willingness was related to past donation, and trust in how researchers use and store biospecimens. However, willingness to donate for cancer research was 76%. Fear of research exploitation and spiritual beliefs decreased willingness. Among those who were generally unwilling to donate, willingness increased if the biobank was run by a Native American organization, if the participant or family member had cancer and this was the disease being studied, if the community was involved in developing, reviewing, and approving the research, and if the expertise of researchers was known. Among those who were willing, willingness decreased if they had never heard of the research organization, and if the biobank was run by the federal government. Participation of AI/AN people in biobanking initiatives is critical to address health inequities and improve the health of AI/AN people, realize personalized medicine goals, and address the limited generalizability of current clinical and biospecimen research. These results highlight areas in which interventions could be developed to increase AI/AN donation of biospecimens for research with the ultimate goal of reducing health disparities.
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作者：
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