Targeted drug delivery in pancreatic cancer.
Targeted drug delivery in pancreatic cancer.
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DOI：
10.1016/j.bbcan.2009.10.001
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发表时间：
2010-01
影响因子：
11.2
通讯作者：
Li, Min
中科院分区：
文献类型：
--
作者：
Yu, Xianjun;Zhang, Yuqing;Chen, Changyi;Yao, Qizhi;Li, Min
有效的药物输送在胰腺癌治疗中仍然是一个主要的挑战。由于对化疗和放射治疗的高度抵抗力，胰腺癌的总体存活率极低。药物递送系统的最新进展为改进癌症治疗带来了巨大的希望。利用脂质体、纳米颗粒和碳纳米管输送抗癌药物和其他治疗药物，如siRNA、自杀基因、溶瘤病毒、小分子抑制剂和抗体，在最近的临床前试验中取得了成功。然而，如何通过配体或抗体定向递送来提高所传递药物的特异性和稳定性是一个主要的问题。因此，迫切需要开发新的、特异的、肿瘤靶向的药物递送系统来治疗这种可怕的疾病。本文综述了近年来胰腺癌靶向给药的研究进展，为胰腺癌治疗的潜在靶点提供了重要信息。
Effective drug delivery in pancreatic cancer treatment remains a major challenge. Because of the high resistance to chemo and radiation therapy, the overall survival rate for pancreatic cancer is extremely low. Recent advances in drug delivery systems hold great promise for improving cancer therapy. Using liposomes, nanoparticles, and carbon nanotubes to deliver cancer drugs and other therapeutic agents such as siRNA, suicide gene, oncolytic virus, small molecule inhibitor and antibody has been a success in recent pre-clinical trials. However, how to improve the specificity and stability of the delivered drug using ligand or antibody directed delivery represent a major problem. Therefore, developing novel, specific, tumor-targeted drug delivery systems is urgently needed for this terrible disease. This review summarizes the current progress on targeted drug delivery in pancreatic cancer, and provides important information on potential therapeutic targets for pancreatic cancer treatment.
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影响因子：
17.1
作者：
Bhirde, Ashwin A.;Patel, Vyomesh;Gavard, Julie;Zhang, Guofeng;Sousa, Alioscka A.;Masedunskas, Andrius;Leapman, Richard D.;Weigert, Roberto;Gutkind, J. Silvio;Rusling, James F.
通讯作者：
Rusling, James F.
DOI：
10.1016/s0360-3016(02)03788-4
发表时间：
2002-11-15
影响因子：
7
作者：
Buchsbaum, DJ;Bonner, JA;Raisch, KP
通讯作者：
Raisch, KP
影响因子：
6.4
作者：
Abela, R. A.;Qian, J.;Zhang, M.
通讯作者：
Zhang, M.
影响因子：
11.2
作者：
Aleku, Manuela;Schulz, Petra;Kaufmann, Joerg
通讯作者：
Kaufmann, Joerg
影响因子：
2.2
作者：
Evoy, D;Hirschowitz, EA;Lieberman, MD
通讯作者：
Lieberman, MD