Regulation of hypaxial muscle development
Regulation of hypaxial muscle development
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DOI：
10.1007/s004410051278
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发表时间：
1999-04-01
影响因子：
3.6
通讯作者：
Dietrich, S
中科院分区：
文献类型：
--
作者：
Dietrich, S
高等脊椎动物的大多数骨骼肌是下轴肌，起源于皮肌切开器的侧唇。各种外部信号汇聚在体节的背外侧象限，以指定轴下肌前体，区分迁移和非迁移细胞，并允许分层的前体注定为长距离迁移。在体节内，Pax3作为轴下肌肉发育的上游调节因子。下游靶点是cMet和Lbx1，它们可以独立地控制迁移性肌肉前体的身份、分化和运动。
The majority of skeletal muscles in higher vertebrates are hypaxial and stem from the lateral lip of the dermomyotomes. Various external signals converge on the dorsolateral quadrant of the somite to specify the hypaxial muscle precursors, to discriminate between migratory and non-migratory cells and to allow delamination of precursors destined for long-range migration. Within the somite, Pax3 acts as upstream regulator of hypaxial muscle development. Downstream targets are cMet and Lbx1, which may independently control identity, differentiation and motility of migratory muscle precursors.