PRECONDITIONING AGAINST MYOCARDIAL DYSFUNCTION AFTER ISCHEMIA AND REPERFUSION BY AN ALPHA-1-ADRENERGIC MECHANISM
PRECONDITIONING AGAINST MYOCARDIAL DYSFUNCTION AFTER ISCHEMIA AND REPERFUSION BY AN ALPHA-1-ADRENERGIC MECHANISM
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DOI：
10.1161/01.res.73.4.656
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发表时间：
1993-10-01
影响因子：
20.1
通讯作者：
HARKEN, AH
中科院分区：
文献类型：
--
作者：
BANERJEE, A;LOCKEWINTER, C;HARKEN, AH
在心脏旁路或移植过程中，预处理可能会在人类面临预定的全局心脏缺血再灌注（IR）时发现现成的适用性，在这种情况下，这种操作在骤停前是可行的。我们的目的是描述和利用由暂时性缺血（TI）触发的内源性预适应机制，从而通过临床可接受的方法减轻心肌缺血后机械功能障碍。经2分钟TI预处理后10分钟正常灌注保护的离体大鼠左心室功能在37℃全缺血20分钟和再灌注40分钟后评估。发育压力的最终恢复（DP）比非条件IR对照组提高了91.5+/-1.9%,57.4+/-2.4%，P
Preconditioning may find ready applicability in humans facing scheduled global cardiac ischemia-reperfusion (IR) during bypass or transplantation, where such a maneuver is feasible before arrest. Our objective was to delineate and exploit the endogenous preconditioning mechanism triggered by transient ischemia (TI) and thereby attenuate myocardial postischemic mechanical dysfunction by clinically acceptable means. Preconditioning by 2 minutes of TI followed by 10 minutes of normal perfusion protected isolated rat left ventricle function assessed after 20 minutes of global, 37-degrees-C ischemia and 40 minutes of reperfusion. Final recovery of developed pressure (DP) was improved (91.5+/-1.9% of equilibration DP versus unconditioned IR control, 57.4+/-2.4%, P