Pharmacokinetics of tablet huperzine A in six volunteers.
Pharmacokinetics of tablet huperzine A in six volunteers.
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发表时间：
1995-09
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通讯作者：
Bo-chu Qian;M. Wang;Zhi-fang Zhou;Kai Chen;Rong-rong Zhou;Guo-shen Chen
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作者：
Bo-chu Qian;M. Wang;Zhi-fang Zhou;Kai Chen;Rong-rong Zhou;Guo-shen Chen
目的研究石杉碱甲片(Hup-A)在中国志愿者体内的药代动力学，为制定其给药方案提供依据。方法6名受试者单次口服0.99 mg后，用反相高效液相色谱法测定0.5、0.75、1.0、1.25、1.5、2、4、6、8、10h的血药浓度，用3P87程序计算药动学参数。结果血药浓度的时程符合一级吸收一室开放模型。药动学参数分别为：T1/2KA=12.6min，T1/2ke=288.5 min，Tmax=79.6min，Cmax=8.4微克L-1，AUC=4.1 mg L-1min。结论Hup-A吸收快，在体内分布广泛，消除速度适中。
AIM To study pharmacokinetics of tablet huperzine A (Hup-A) in Chinese volunteers to help establishing its drug administration schedule. METHODS For 6 volunteers after a single oral dose of 0.99 mg, drug concentrations in plasma were assayed by reverse phase high pressure liquid chromatography (HPLC) at 0.5, 0.75, 1.0, 1.25, 1.5, 2, 4, 6, 8, and 10 h. The pharmacokinetic parameters were calculated with a 3P87 program by computer. RESULTS The time course of plasma concentrations conformed to a one-compartment open model with a first order absorption. The pharmacokinetic parameters were as follows: T 1/2ka = 12.6 min, T 1/2ke = 288.5 min, Tmax = 79.6 min, Cmax = 8.4 micrograms L-1, AUC = 4.1 mg L-1 min. CONCLUSION Hup-A was absorbed rapidly, distributed widely in the body, and eliminated at a moderate rate.