The dynamics of acute malaria infections. I. Effect of the parasite's red blood cell preference
The dynamics of acute malaria infections. I. Effect of the parasite's red blood cell preference
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DOI：
10.1098/rspb.2008.0198
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发表时间：
2008-06-22
影响因子：
4.7
通讯作者：
de Roode, Jacobus C.
中科院分区：
文献类型：
--
作者：
Antia, Rustom;Yates, Andrew;de Roode, Jacobus C.
在急性原发性疟疾感染期间，是什么决定了寄生虫和贫血的动态？为什么有些疟疾菌株比其他菌株的密度更高，造成的贫血更严重？传统观点认为，复制最快的寄生虫达到最高密度，并导致红细胞（RBC）的最大损失。目前的其他假设表明，最大的寄生虫密度是由引起最弱的免疫反应或感染最年轻的红细胞（网织红细胞）的菌株实现的。另一个假设是一个简单的资源限制模型，其中在感染急性期的峰值寄生虫密度和最大贫血（红细胞损失百分比）等于疟疾寄生虫可以感染的红细胞比例。我们区分这些假设之间的发展急性疟疾感染的数学模型，并面对它与实验数据从啮齿动物疟原虫夏氏疟原虫。我们表明，资源限制模型可以解释感染不同菌株的这种寄生虫的小鼠的初始动力学。我们进一步测试了该模型，表明在没有修改的情况下，它密切再现了竞争菌株与这些菌株的夏氏疟原虫混合感染小鼠的动态。我们的研究结果表明，一个简单的资源限制是能够捕捉的基本特征的动态寄生虫和红细胞损失在急性疟疾感染的小鼠与P.查鲍迪，这表明它可能是值得探索的，如果类似的结果可能适用于其他急性疟疾感染，包括人类。
What determines the dynamics of parasite and anaemia during acute primary malaria infections? Why do some strains of malaria reach higher densities and cause greater anaemia than others? The conventional view is that the fastest replicating parasites reach the highest densities and cause the greatest loss of red blood cells (RBCs). Other current hypotheses suggest that the maximum parasite density is achieved by strains that either elicit the weakest immune responses or infect the youngest RBCs (reticulocytes). Yet another hypothesis is a simple resource limitation model where the peak parasite density and the maximum anaemia (percentage loss of RBCs) during the acute phase of infection equal the fraction of RBCs that the malaria parasite can infect. We discriminate between these hypotheses by developing a mathematical model of acute malaria infections and confronting it with experimental data from the rodent malaria parasite Plasmodium chabaudi. We show that the resource limitation model can explain the initial dynamics of infection of mice with different strains of this parasite. We further test the model by showing that without modification it closely reproduces the dynamics of competing strains in mixed infections of mice with these strains of P. chabaudi. Our results suggest that a simple resource limitation is capable of capturing the basic features of the dynamics of both parasite and RBC loss during acute malaria infections of mice with P. chabaudi, suggesting that it might be worth exploring if similar results might hold for other acute malaria infections, including those of humans.