Do Plasma Concentrations of Δ9‐Tetrahydrocannabinol Reflect the Degree of Intoxication?
Do Plasma Concentrations of Δ9‐Tetrahydrocannabinol Reflect the Degree of Intoxication?
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Δ9-四氢大麻酚的血浆浓度是否反映了中毒程度？
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
S. Agurell
中科院分区：
文献类型：
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作者：
Leo E. Hollister;H. Gillespie;A. Ohlsson;Jan;A. Wahlén;S. Agurell;S. Agurell
摘要：采用气液相色谱和质谱法测定三种给药途径下四氢大麻酚的血浆浓度，并与临床疗效进行相关性分析。静脉注射后3分钟血药浓度达到峰值，随后急剧下降。高峰“高”发生在30分钟，而血浆浓度下降。这种血浆浓度与“高”之间的滞后在药物作用的大部分时间内持续存在。吸烟后的情况与吸烟后非常相似，只是峰值血浆浓度较低。口服四氢大麻酚后，吸收缓慢，浓度峰值出现在1 ~ 2小时。血浆浓度要低得多。血浆药物浓度与“高”之间的相关性显著，但并不令人印象深刻。“高”的程度与当时的血浆浓度有很大的不同。结膜注射时，只要能测出四氢大麻酚的血浆浓度即可。与其他两种途径相比，口服给药浓度较低时脉搏率增加。血浆浓度范围不太可能可靠地等同于性能受损。如果四氢大麻酚或其同系物成为治疗剂，给药方式将变得重要。
Abstract: Plasma concentrations of THC were measured by gas‐liquid chromatography and mass spectrometry following three routes of administration and correlated with clinical effects. Plasma concentrations peaked at 3 minutes after intravenous injection and then sharply declined. The peak “high” occurred at 30 minutes while plasma concentrations were declining. This lag between plasma concentration and “high” continued during most of the span of the drug's effects. The situation was quite similar following smoking, except that peak plasma concentrations were lower. After oral administration of THC, absorption was slow, with peak concentration occurring at 1 to 2 hours. Plasma concentrations were much lower. Correlations between plasma concentrations of drug and “high” were significant but not impressive. The degree of “high” was quite variable in relation to the prevailing plasma concentration. Conjunctival injection was found so long as plasma concentration of THC could be measured. Pulse rate increases occurred at lower concentration after oral administration than after the other two routes. It is unlikely that a range of plasma concentrations can be reliably equated with impaired performance. The mode of administration will become important should THC or some homolog become a therapeutic agent.