Working memory maintenance of grasp-target information in the human posterior parietal cortex
Working memory maintenance of grasp-target information in the human posterior parietal cortex
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DOI：
10.1016/j.neuroimage.2010.09.080
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发表时间：
2011-02-01
期刊：
影响因子：
5.7
通讯作者：
Roesler, Frank
中科院分区：
文献类型：
--
作者：
Fiehler, Katja;Bannert, Michael M.;Roesler, Frank
事件相关功能磁共振成像被应用于确定参与维持目标信息在工作记忆中用于即将到来的抓握动作的皮层区域。参与者必须用右手的拇指和食指抓住不同大小和方向的三维物体。到达抓取运动进行没有视觉反馈后立即对象呈现或经过2-12秒的可变延迟。右下顶叶皮层表现出持续的神经活动在整个延迟，重叠的抓目标的编码过程中观察到的活动。立即和延迟抓握激活了类似的运动相关脑区，并没有显示出差异活动。结果表明，右下顶叶皮层在抓握相关信息的工作记忆维持中起着重要的功能作用。此外，我们的研究结果证实了这样的假设：负责维护信息的大脑区域也参与编码相同的信息，从而将之前关于后顶叶皮质在扫视行为中的工作记忆功能的发现扩展到了伸手抓取运动。(C)2010年爱思唯尔公司All rights reserved.
Event-related functional magnetic resonance imaging was applied to identify cortical areas involved in maintaining target information in working memory used for an upcoming grasping action. Participants had to grasp with their thumb and index finger of the dominant right hand three-dimensional objects of different size and orientation. Reaching-to-grasp movements were performed without visual feedback either immediately after object presentation or after a variable delay of 2-12 s. The right inferior parietal cortex demonstrated sustained neural activity throughout the delay, which overlapped with activity observed during encoding of the grasp target. Immediate and delayed grasping activated similar motor-related brain areas and showed no differential activity. The results suggest that the right inferior parietal cortex plays an important functional role in working memory maintenance of grasp-related information. Moreover, our findings confirm the assumption that brain areas engaged in maintaining information are also involved in encoding the same information, and thus extend previous findings on working memory function of the posterior parietal cortex in saccadic behavior to reach-to-grasp movements. (C) 2010 Elsevier Inc. All rights reserved.