Immunoglobulin G: a potential treatment to attenuate neuroinflammation following spinal cord injury.
Immunoglobulin G: a potential treatment to attenuate neuroinflammation following spinal cord injury.
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DOI：
10.1007/s10875-010-9404-7
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发表时间：
2010-05
影响因子：
9.1
通讯作者：
Nguyen, Dung H.
中科院分区：
文献类型：
--
作者：
Fehlings, Michael G.;Nguyen, Dung H.
脊髓损伤（SCI）是由两种相关但机制不同的事件引起的：脊髓的原发性损伤是由机械创伤引起的;继发性损伤是加剧初始损伤的细胞和分子事件的级联反应。神经炎症是继发性损伤级联反应中的重要事件，在SCI后细胞碎片的清除中至关重要。然而，白细胞和小胶质细胞在神经炎症过程中被招募到损伤部位，可以通过分泌活性氧、基质金属蛋白酶和促炎细胞因子来加剧SCI后的初始损伤。因此，减弱白细胞和小胶质细胞的活性是减少与SCI相关的神经功能缺损的有吸引力的治疗策略。在这方面，免疫球蛋白G（IgG）是一种潜在的治疗候选者。IgG已在临床上用于治疗自身免疫性疾病，并已被证明可减弱白细胞和小胶质细胞的活性。本文就IgG的免疫调节机制和神经炎症在SCI中的作用进行综述，并探讨其在SCI中的应用前景。
Spinal cord injury (SCI) is caused by two related but mechanistically distinct events: the primary injury to the spinal cord is caused by a mechanic trauma; the secondary injury is a cascade of cellular and molecular events that exacerbates the initial damage. Neuroinflammation, an important event in the secondary injury cascade, is critical in the clearance of cellular debris after SCI. However, leukocytes and microglia, recruited to the injury site during neuroinflammation, can exacerbate the initial damage following SCI by secreting reactive oxygen species, matrix-metalloproteinase, and proinflammatory cytokines. Therefore, attenuating the activity of leukocytes and microglia is an attractive therapeutic strategy to reduce the neurological deficit associated with SCI. In this regard, immunoglobulin G (IgG) is a potential treatment candidate. IgG has been used clinically to treat autoimmune disease and has been demonstrated to attenuate the activities of leukocytes and microglia. In this review, we discuss the potential use of IgG for SCI based on the current understanding of the immune-modulating mechanism of IgG and the role of neuroinflammation in SCI.
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