Anti-sulfatide IgM antibodies in peripheral neuropathy
Anti-sulfatide IgM antibodies in peripheral neuropathy
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DOI：
10.1016/s0022-510x(00)00342-7
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发表时间：
2000-06-15
影响因子：
4.4
通讯作者：
Nobile-Orazio, E
中科院分区：
文献类型：
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作者：
Carpo, M;Meucci, N;Nobile-Orazio, E
最近发现抗硫苷脂 IgM 抗体与神经病变相关，但这种反应性的临床和电生理学相关性仍不清楚。我们回顾了1991年至1998年本实验室检测到的高抗硫脑苷脂滴度患者的临床和电生理特征。通过酶联免疫吸附试验（ELISA）检测了564例不同神经系统诊断的患者，其中11例抗硫苷脂IgM高滴度（>1/8000），26例滴度为1/8000，78例滴度为1/4000。所有具有高抗硫苷脂 IgM 滴度的患者都患有慢性、免疫失调、主要是感觉运动神经病，其中 7 名患者与 IgM 单克隆丙种球蛋白病相关。在大多数这些患者中，电生理学和形态学研究与主要脱髓鞘性神经病一致，通常与显着的轴突损失相关。 118000 的抗体滴度虽然总是与神经病变相关，但与神经病变的特定形式或原因无关，而较低的滴度在患有不同神经系统疾病的患者中平均分布。我们的研究表明，高抗硫苷脂 IgM 滴度 (>1/8000) 高度预测慢性、免疫失调、大多为脱髓鞘性神经病，通常与 IgM 单克隆丙种球蛋白病相关，因此可能具有潜在的诊断相关性。 (C) 2000 Elsevier Science B.V. 保留所有权利。
Anti-sulfatide IgM antibodies have been recently associated with neuropathy but the clinical and electrophysiological correlations of this reactivity remains unclear. We reviewed the clinical and electrophysiological features of patients with high anti-sulfatide titers detected in our laboratory from 1991 to 1998. Of the 564 patients with different neurological diagnosis tested by enzyme-linked immunosorbent assay (ELISA), 11 had high anti-sulfatide IgM titers (>1/8000), 26 had titers of 1/8000 while 78 had titers of 1/4000. All patients with high anti-sulfatide IgM titers had a chronic, dysimmune, mostly sensorimotor neuropathy that in seven was associated with IgM monoclonal gammopathy. In most of these patients electrophysiological and morphological studies were consistent with a predominantly demyelinating neuropathy frequently associated with prominent axonal loss. Antibody titers of 118000, though always associated with neuropathy, did not correlate with a particular form or cause of neuropathy, while lower titers were equally distributed in patients with different neurological disorders. Our study indicate that high anti-sulfatide IgM titers (>1/8000) are highly predictive for a chronic, dysimmune, mostly demyelinating neuropathy often associated with IgM monoclonal gammopathy, and may therefore have potential diagnostic relevance. (C) 2000 Elsevier Science B.V. All rights reserved.