The biological role of estrogen receptors alpha and beta in cancer.
The biological role of estrogen receptors alpha and beta in cancer.
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发表时间：
2004
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通讯作者：
S. Pearce;V. Jordan
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作者：
S. Pearce;V. Jordan
雌激素的时间和组织特异性作用由雌激素受体α和β介导。ER是类固醇激素受体，当与配体结合时调节靶基因的转录。这些转录因子的活性受多种因素调节，包括配体结合、磷酸化、辅助调节因子和效应子途径（ERE、AP 1、SP 1）。靶基因转录的最终结果是调节生理过程，如生殖器官发育和功能，骨密度，不幸的是有助于乳腺癌和子宫内膜癌的生长和发展。由ER α和ER β介导的复杂生物学效应涉及许多蛋白质和信号通路之间的通信。目前研究的最终目标是提高单独雌激素受体作为治疗干预靶点的价值。
The temporal and tissue-specific actions of estrogen are mediated by estrogen receptors alpha and beta. The ERs are steroid hormone receptors that modulate the transcription of target genes when bound to ligand. The activity of these transcription factors is regulated by a variety of factors, including ligand binding, phosphorylation, coregulators, and the effector pathway (ERE, AP1, SP1). The end result of target gene transcription is to modulate physiological processes, such as reproductive organ development and function, bone density, and unfortunately contribute to the growth and development of breast and endometrial cancer. The complex biological effects mediated by ER alpha and ER beta involve communication between many proteins and signaling pathways. An ultimate goal of current research is to enhance the value of the separate estrogen receptors as targets for therapeutic intervention.