High-resolution fMRI reveals laminar differences in neurovascular coupling between positive and negative BOLD responses.
High-resolution fMRI reveals laminar differences in neurovascular coupling between positive and negative BOLD responses.
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DOI：
10.1016/j.neuron.2012.09.019
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发表时间：
2012-11-08
期刊：
影响因子：
16.2
通讯作者：
Logothetis NK
中科院分区：
文献类型：
--
作者：
Goense J;Merkle H;Logothetis NK
这六个大脑皮层具有不同的解剖和生理特性，如不同的能量使用和不同的前馈和反馈连接。目前还不知道fMRI信号中是否以及如何反映了特定层级的神经过程。为了解决这个问题，我们使用高分辨率fMRI来测量BOLD、CBV和CBF对刺激的反应，这些刺激在猕猴初级视觉皮质中引发了积极和消极的BOLD信号。我们发现，有积极大胆反应的区域CBV和CBF平行增加，而消极大胆反应区域的CBF减少，但CBV增加。对于积极的BOLD反应，大脑皮质中央的CBF和CBV增加，而对于消极的BOLD反应，CBF表面减少，CBV在中央增加。我们的发现提示BOLD增加和减少的神经血管偶联的不同机制，以及神经血管偶联的层状差异。
The six cortical layers have distinct anatomical and physiological properties, like different energy use and different feedforward and feedback connectivity. It is not known if and how layer-specific neural processes are reflected in the fMRI signal. To address this question we used high-resolution fMRI to measure BOLD, CBV, and CBF responses to stimuli that elicit positive and negative BOLD signals in macaque primary visual cortex. We found that regions with positive BOLD responses had parallel increases in CBV and CBF, whereas areas with negative BOLD responses showed a decrease in CBF but an increase in CBV. For positive BOLD responses, CBF and CBV increased in the center of the cortex, but for negative BOLD responses, CBF decreased superficially while CBV increased in the center. Our findings suggest different mechanisms for neurovascular coupling for BOLD increases and decreases, as well as laminar differences in neurovascular coupling.