Biochemical, behavioral, physiologic, and neurodevelopmental changes in mice deficient in monoamine oxidase A or B
Biochemical, behavioral, physiologic, and neurodevelopmental changes in mice deficient in monoamine oxidase A or B
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DOI：
10.1016/s0361-9230(01)00613-x
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发表时间：
2001-11-15
影响因子：
3.8
通讯作者：
Shih, JC
中科院分区：
文献类型：
--
作者：
Holschneider, DP;Chen, K;Shih, JC
缺乏单胺氧化酶A或单胺氧化酶B的突变小鼠的可用性在5-羟色胺、去甲肾上腺素、多巴胺和苯乙胺的中枢和外周可用性方面产生了独特的特征。本文总结了一些目前已知的单胺氧化酶A基因敲除小鼠的表型研究结果，并与单胺氧化酶B基因敲除小鼠进行了比较。差异进行了讨论有关的生化，行为和生理变化的调查，以及冗余机制，适应性反应和神经发育的改变所发挥的作用。(C)2001 Elsevier Science Inc.
The availability of mutant mice that lack either MAO A or MAO B has created unique profiles in the central and peripheral availability of serotonin, norepinephrine, dopamine, and phenylethylamine. This paper summarizes some of the current known phenotypic findings in MAO A knock-out mice and contrast these with those of MAO B knock-out mice. Differences are discussed in relation to the biochemical, behavioral, and physiologic changes investigated to date, as well as the role played by redundancy mechanisms, adaptational responses, and alterations in neurodevelopment. (C) 2001 Elsevier Science Inc.