Hypertension in Pregnancy and Later Cardiovascular Risk Common Antecedents?
Hypertension in Pregnancy and Later Cardiovascular Risk Common Antecedents?
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DOI：
10.1161/circulationaha.110.943407
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发表时间：
2010-08-10
期刊：
影响因子：
37.8
通讯作者：
Vatten, Lars J.
中科院分区：
文献类型：
--
作者：
Romundstad, Pal R.;Magnussen, Elisabeth B.;Vatten, Lars J.
背景-先兆子痫和妊娠期高血压与日后心血管疾病风险增加有关。我们已经评估了是否可以归因于因素，在怀孕期间或孕前的危险因素，是共享的两个disorders.Methods和结果，纵向数据从2个连续波的挪威人口为基础的研究（北-特龙德拉格健康研究[HUNT]）相结合的数据从医学出生登记处挪威。在24865名参加了HUNT 1和2的妇女中，我们确定了3225名在2项研究中有单胎分娩的妇女，她们进行了标准化的血压、血脂和体重指数测量。初步结果显示，与其他女性相比，在妊娠期经历先兆子痫或妊娠期高血压的女性具有显著较高的体重指数和收缩压和舒张压以及不利的血脂水平。然而，在调整孕前测量值后，体重指数的差异减弱了> 65%，血压的差异减弱了约50%。在高密度脂蛋白胆固醇和甘油三酯，各组之间的差异分别衰减了40%和72%，foreign. Conclusions这些结果表明，先兆子痫和妊娠期高血压与孕后心血管危险因素的正相关可能是由于在很大程度上共享孕前危险因素，而不是反映在怀孕期间的高血压疾病的直接影响。（循环。2010;122：579-584）。
Background-Preeclampsia and gestational hypertension are associated with increased risk for cardiovascular disease later in life. We have assessed whether the effect can be attributed to factors that operate in pregnancy or to prepregnancy risk factors that are shared by both disorders.Methods and Results-Longitudinal data from 2 consecutive waves of a Norwegian population-based study (the Nord-Trondelag Health Study [HUNT]) were combined with data from the Medical Birth Registry of Norway. Among 24 865 women who had participated in both HUNT 1 and 2, we indentified 3225 women with a singleton birth between the 2 studies who had standardized measurements of blood pressure, serum lipids, and body mass index. The crude results showed that women who experienced preeclampsia or gestational hypertension in pregnancy had substantially higher levels of body mass index and systolic and diastolic blood pressures and unfavorable lipids compared with other women. However, after adjustment for prepregnancy measurements, the difference in body mass index was attenuated by >65%, and the difference in blood pressure was attenuated by approximate to 50%. In relation to high-density lipoprotein cholesterol and triglycerides, differences between the groups were attenuated by 40% and 72%, respectively.Conclusions-These results suggest that the positive association of preeclampsia and gestational hypertension with postpregnancy cardiovascular risk factors may be due largely to shared prepregnancy risk factors rather than reflecting a direct influence of the hypertensive disorder in pregnancy. (Circulation. 2010;122:579-584.)