Prospective Associations between Emotion Dysregulation and Fear-Potentiated Startle: The Moderating Effect of Respiratory Sinus Arrhythmia.
Prospective Associations between Emotion Dysregulation and Fear-Potentiated Startle: The Moderating Effect of Respiratory Sinus Arrhythmia.
复制标题
DOI：
10.3389/fpsyg.2016.00652
复制
发表时间：
2016
影响因子：
3.8
通讯作者：
Norrholm SD
中科院分区：
文献类型：
--
作者：
Seligowski AV;Lee DJ;Miron LR;Orcutt HK;Jovanovic T;Norrholm SD
背景：情绪失调与创伤暴露后的不良后果有关。一个被提出的情绪失调的生物标志物，呼吸性窦性心律失常（RSA），已经证明与创伤相关的现象，如恐惧增强惊吓（FPS）反应。本研究旨在探讨创伤暴露数年后情绪失调与RSA和FPS之间的前瞻性关联。方法：研究对象为2008年2月14日校园枪击案中的131名女性。2006 - 2008年对射击前情绪失调进行了评估。在2012年至2015年进行的FPS范例中收集了通过眼轮匝肌肌电图（EMG）测量的惊吓反应和RSA。结果：在整个样本中，情绪失调、RSA和FPS之间没有显著的关联。然而，在高静息RSA个体中，情绪失调预测了获得（r = 0.40，p <0.05）和消退（r = 0.57，p <0.01）期间的FPS。结论：研究结果表明，射击前情绪失调是潜在创伤暴露后几年FPS的一个有效预测因子，这种关联因RSA水平而异。结果强调了检查自主神经调节的重要性，在情绪失调和创伤暴露恢复之间的关联。
Background: Emotion dysregulation has been implicated in the negative outcomes following trauma exposure. A proposed biomarker of emotion dysregulation, respiratory sinus arrhythmia (RSA), has demonstrated associations with trauma-related phenomena, such as the fear-potentiated startle (FPS) response. The current study aimed to examine the prospective association between emotion dysregulation and RSA and FPS several years following trauma exposure. Methods: Participants were 131 women exposed to a campus mass shooting on February 14, 2008. Pre-shooting emotion dysregulation was assessed in 2006–2008. Startle response, measured by orbicularis oculi electromyography (EMG), and RSA were gathered during an FPS paradigm conducted from 2012 to 2015. Results: No significant associations among emotion dysregulation, RSA, and FPS emerged among the full sample. However, emotion dysregulation predicted FPS during both acquisition (r = 0.40, p < 0.05) and extinction (r = 0.57, p < 0.01) among individuals with high resting RSA. Conclusions: Findings suggest that pre-shooting emotion dysregulation is a potent predictor of FPS several years following potential trauma exposure, and this association varies by RSA level. Results emphasize the importance of examining autonomic regulation in the association between emotion dysregulation and recovery from trauma exposure.