Codetection of Respiratory Syncytial Virus in Habituated Wild Western Lowland Gorillas and Humans During a Respiratory Disease Outbreak
Codetection of Respiratory Syncytial Virus in Habituated Wild Western Lowland Gorillas and Humans During a Respiratory Disease Outbreak
复制标题
DOI：
10.1007/s10393-016-1144-6
复制
发表时间：
2016-09-01
期刊：
影响因子：
2.5
通讯作者：
Leendertz, Fabian H.
中科院分区：
文献类型：
--
作者：
Gruetzmacher, Kim S.;Koendgen, Sophie;Leendertz, Fabian H.
肺病毒已被确定为几种习惯性野生类人猿呼吸道疾病暴发的病原体。根据系统发育证据，很可能是从人类传播的。然而，在疫情爆发之前或同时，从未在当地人群中检测到病原体。在这里，我们报告的第一个同时检测到人类呼吸道合胞病毒（HRSV）感染西部低地大猩猩（大猩猩大猩猩）和当地人口在中非共和国的实地计划。共对15只大猩猩和15份人类粪便样本以及80份人类咽拭子进行了HRSV、人类偏肺病毒和其他呼吸道病毒检测。我们能够从四只大猩猩和四个人身上获得相同的HRSV A序列。相比之下，我们没有检测到HRSV或任何其他经典的人类呼吸道病毒在大猩猩粪便样本在其他两个爆发在同一领域的计划。检测到肠道病毒序列，但这些病毒在这些暴发的病因学中的意义仍然是推测性的。我们在野生但人类习惯的大猩猩中发现HRSV，再次强调了从人类到濒危类人猿的种间传播风险。
Pneumoviruses have been identified as causative agents in several respiratory disease outbreaks in habituated wild great apes. Based on phylogenetic evidence, transmission from humans is likely. However, the pathogens have never been detected in the local human population prior to or at the same time as an outbreak. Here, we report the first simultaneous detection of a human respiratory syncytial virus (HRSV) infection in western lowland gorillas (Gorilla gorilla gorilla) and in the local human population at a field program in the Central African Republic. A total of 15 gorilla and 15 human fecal samples and 80 human throat swabs were tested for HRSV, human metapneumovirus, and other respiratory viruses. We were able to obtain identical sequences for HRSV A from four gorillas and four humans. In contrast, we did not detect HRSV or any other classic human respiratory virus in gorilla fecal samples in two other outbreaks in the same field program. Enterovirus sequences were detected but the implication of these viruses in the etiology of these outbreaks remains speculative. Our findings of HRSV in wild but human-habituated gorillas underline, once again, the risk of interspecies transmission from humans to endangered great apes.