Propagation and amplification of molecular information using a photoresponsive molecular switch
Propagation and amplification of molecular information using a photoresponsive molecular switch
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DOI：
10.1080/10610270802468439
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发表时间：
2009-01-01
影响因子：
3.3
通讯作者：
Suda, Tatsuya
中科院分区：
文献类型：
--
作者：
Mukai, Masaru;Maruo, Kohei;Suda, Tatsuya
分子通信是一种以分子为信息载体的仿生通信模式。分子通信系统包括信息载体分子在分子发送器和分子接收器之间的传播，随后在接收器处放大信息。在这篇文章中，我们建立了一个示例分子通讯系统使用双子肽脂质作为分子开关。嵌入在脂质双层膜中的分子开关表现出对金属离子（如Cu 2+和Zn 2+）的光响应识别行为，以控制由小脂质体形成的分子胶囊向巨型脂质体接收器的传播。此外，分子开关作为一个人工受体的接收器，接收光子信号与酶作为信号放大器，通过使用铜离子作为介体之间的受体和放大器。
Molecular communication is a bio-inspired communication paradigm using molecules as information carriers. The molecular communication system includes propagation of information carrier molecules between a molecular sender and a molecular receiver and followed by amplification of the information at the receiver. In this article, we built an example molecular communication system using a gemini peptide lipid as a molecular switch. The molecular switch embedded in the lipid bilayer membranes exhibited photoresponsive recognition behaviour towards metal ions, such as Cu2+ and Zn2+, to control propagation of molecular capsules formed by small liposomes to a giant liposomal receiver. In addition, the molecular switch acted as an artificial receptor in the receiver, receiving a photonic signal to communicate with an enzyme as a signal amplifier by using Cu2+ ion as a mediator between the receptor and the amplifier.