annoPeak: a web application to annotate and visualize peaks from ChIP-seq/ChIP-exo-seq.
annoPeak: a web application to annotate and visualize peaks from ChIP-seq/ChIP-exo-seq.
复制标题
annoPeak：一个 Web 应用程序，用于注释和可视化 ChIP-seq/ChIP-exo-seq 中的峰。
DOI：
10.1093/bioinformatics/btx016
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Leone,Gustavo
中科院分区：
文献类型：
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作者：
Tang,Xing;Srivastava,Arunima;Liu,Huayang;Machiraju,Raghu;Huang,Kun;Leone,Gustavo
摘要我们开发了AnnoPeak，这是一款Web应用程序，用于注释、可视化和比较使用人类和小鼠细胞进行的芯片序列/芯片外源序列实验中预测的蛋白质结合区。用户可以将多个实验的峰区上传到AnnoPeak服务器上，用生物学背景对它们进行注释，识别相关的目标基因，并根据基因结构对结合位点进行分类。用户还可以借助AnnoPeak提供的可视化工具和表格，直观地比较多个绑定配置文件。总的来说，AnnoPeak将帮助用户识别全基因组转录因子结合图谱的模式，评估不同生物背景下的结合图谱，并产生新的假设。可用性和实施该网络服务可通过网址：https://apps.medgen.iupui.edu/rsc/content/19/.免费访问源代码可在https://github.com/XingTang2014/annoPeak.Supplementary信息上找到补充数据可在生物信息学在线上找到。
SummaryWe developed annoPeak, a web application to annotate, visualize and compare predicted protein-binding regions derived from ChIP-seq/ChIP-exo-seq experiments using human and mouse cells. Users can upload peak regions from multiple experiments onto the annoPeak server to annotate them with biological context, identify associated target genes and categorize binding sites with respect to gene structure. Users can also compare multiple binding profiles intuitively with the help of visualization tools and tables provided by annoPeak. In general, annoPeak will help users identify patterns of genome wide transcription factor binding profiles, assess binding profiles in different biological contexts and generate new hypotheses.Availability and ImplementationThe web service is freely accessible through URL: https://apps.medgen.iupui.edu/rsc/content/19/. Source code is available at https://github.com/XingTang2014/annoPeak.Supplementary informationSupplementary data are available atBioinformaticsonline.