Loss of independent limb control in childhood hemiparesis is related to time of brain injury onset
Loss of independent limb control in childhood hemiparesis is related to time of brain injury onset
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DOI：
10.1007/s00221-012-3385-0
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发表时间：
2013-03-01
影响因子：
2
通讯作者：
Dewald, Julius P. A.
中科院分区：
文献类型：
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作者：
Sukal-Moulton, Theresa;Murray, Theresa M.;Dewald, Julius P. A.
本研究调查了儿童期轻偏瘫患者手肘关节的肢体间活动，包括单侧任务期间自发的镜像运动和双侧任务期间抑制它们的能力。将18名轻偏瘫患者分为三类损伤时间：出生前（产前），出生前后（围产期）和6个月后（产后）。轻偏瘫的个人，以及12个典型的发展同行，参加了在最大和次最大努力完成的单侧和双侧肘关节屈曲和伸展任务，同时监测肌肉活动和运动输出量化两个多自由度的负荷传感器。值得注意的是，只有在产前和围产期组中发现更高水平的麻痹性肘关节屈曲在屈曲的非麻痹性肢体，这是调制的努力水平在单边和双边的任务。在产前/围产期组中肘屈肌的双侧激活表明可能使用共同的皮质命令源来驱动两个上肢，而产后/典型发育组的屈肌似乎从不同的脊髓上结构接收输入。
This study investigated the presence of inter-limb activity at the elbow joint in individuals with childhood-onset hemiparesis, including spontaneous mirror movements during unilateral tasks and the ability to suppress them during bilateral tasks. Eighteen individuals with hemiparesis were divided into three categories of injury timing: before birth (PRE-natal), around the time of birth (PERI-natal), and after 6 months of age (POST-natal). Individuals with hemiparesis, as well as 12 typically developing peers, participated in unilateral and bilateral elbow flexion and extension tasks completed at maximal and submaximal effort while muscle activity was monitored and motor output was quantified by two multiple degrees-of-freedom load cells. Significantly, higher levels of paretic elbow flexion were found only in the PRE- and PERI-natal groups during the flexion of the non-paretic limb, which was modulated by effort level in both unilateral and bilateral tasks. The bilateral activation of elbow flexors in the PRE-/PERI-natal groups indicates potential use of a common cortical command source to drive both upper extremities, while the POST-natal/typically developing groups' flexors appear to receive input from different supraspinal structures.