Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation
Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation
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DOI：
10.1016/j.ceb.2008.03.006
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发表时间：
2008-06-01
影响因子：
7.5
通讯作者：
Kraus, W. Lee
中科院分区：
文献类型：
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作者：
Kraus, W. Lee
基因表达的调节需要大量的蛋白质因子，这些蛋白质因子可以调节染色质结构，在增强子处起作用，作为转录辅助调节子起作用，或者调节绝缘子功能。聚（ADP-核糖）聚合酶-1（PARP-1）是一种丰富且普遍存在的核酶，其催化ADP-核糖聚合物在多种核蛋白上的NAD（+）依赖性加成，已涉及所有这些功能。最近的生物化学，基因组学，蛋白质组学和细胞为基础的研究已经强调了PARP-1在这些过程中的作用，并提供了新的见解的分子机制，管理PARP-1依赖的基因表达调控。此外，这些研究已经证明了PARP-1如何作为细胞信号通路的组成部分发挥作用，最终导致基因调控结果。
The regulation of gene expression requires a wide array of protein factors that can modulate chromatin structure, act at enhancers, function as transcriptional coregulators, or regulate insulator function. Poly(ADP-ribose) pblymerase-1 (PARP-1), an abundant and ubiquitous nuclear enzyme that catalyzes the NAD(+)-dependent addition of ADP-ribose polymers on a variety of nuclear proteins, has been implicated in all of these functions. Recent biochemical, genomic, proteomic, and cell-based studies have highlighted the role of PARP-1 in each of these processes and provided new insights about the molecular mechanisms governing PARP-1-dependent regulation of gene expression. In addition, these studies have demonstrated how PARP-1 functions as an integral part of cellular signaling pathways that culminate in gene-reguiatory outcomes.