Self-paced frequency of a simple motor task and brain activation An fMRI study in healthy subjects using an on-line monitor device
Self-paced frequency of a simple motor task and brain activation An fMRI study in healthy subjects using an on-line monitor device
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DOI：
10.1016/j.neuroimage.2007.07.045
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发表时间：
2007-11-15
期刊：
影响因子：
5.7
通讯作者：
Mascalchi, Mario
中科院分区：
文献类型：
--
作者：
Diciotti, Stefano;Gavazzi, Cinzia;Mascalchi, Mario
功能磁共振成像在临床神经病学的应用意味着选择一个简单的任务和控制的任务执行。因此，客观地监测与任务执行相关的变量的能力是重要的，并且可以提高临床fMRI研究的准确性。我们评估了健康受试者在简单运动任务中不同自主频率对大脑激活的影响。开发了一种装置，用于测量受试者用优势手的最后四个手指按压充气橡胶球时所施加的力。通过对力信号的分析确定任务频率。9名健康受试者以自步速慢（0.35 +/非0.09 Hz的超集）、中间（0.58+/非0.21 Hz的超集）或快（0.98+/非0.32 Hz的超集）频率执行两次任务。器械显示受试者的任务执行受损。慢、中、快节奏作业的频率变异系数分别为8.7%、12.2%和15.8%。比较对侧感觉运动皮层和同侧小脑在慢、中、快频率下获得的激活图，没有发现显著差异。聚类重复性好的位置（标准差
Application of fMRI to clinical neurology implies the selection of a simple task and control of the task performance. The capability to objectively monitor variables related to task execution is, therefore, important and could improve accuracy of clinical fMRI studies. We assessed the influence of different self-paced frequencies of a simple motor task on brain activation in healthy subjects. A device was developed to measure the force exerted by a subject in pressing an air-filled rubber bulb with the last four fingers of the dominant hand. The task frequency was determined by analysis of the force signal. Nine healthy subjects performed twice the task with self-paced slow (0.35 +/not superset of 0.09 Hz), intermediate (0.58+/not superset of 0.21 Hz) or fast (0.98+/not superset of 0.32 Hz) frequency. The device revealed impaired task execution in I subject. The coefficient of variation of frequency was 8.7% for slow, 12.2% for intermediate and 15.8% for fast paced task. No significant differences were found comparing the activation maps obtained at slow, intermediate and fast frequencies in the contralateral sensorimotor cortex and ipsilateral cerebellum. Cluster reproducibility was good for location (standard deviation