Inkjet printing for pharmaceutical applications
Inkjet printing for pharmaceutical applications
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DOI：
10.1016/j.mattod.2014.04.027
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发表时间：
2014-06-01
期刊：
影响因子：
24.2
通讯作者：
Narayan, Roger J.
中科院分区：
文献类型：
--
作者：
Boehm, Ryan D.;Miller, Philip R.;Narayan, Roger J.
咪康唑是一种用于治疗真菌感染的咪唑，其在极性溶剂（如水溶液）中的溶解度较差。微针是一种小型的矛形装置，通常用于药物制剂和疫苗的输送，由酸酐共聚物使用可见光动态掩膜微立体光刻/微成型制成，并使用压电喷墨打印机加载咪康唑。微针在Sabouraud葡萄糖琼脂上对白色念珠菌（ATCC 90028）具有生物降解和抗真菌活性。研究结果表明，压电喷墨打印可用于微针和其他药物输送装置。采用可见光动态掩膜微立体光刻-微成型-压电喷墨打印方法制备的微针在皮肤真菌感染的透皮治疗中具有潜在的应用前景。
Miconazole is an imidazole used for treatment of fungal infections that exhibits poor solubility in polar solvents (e.g., aqueous solutions). Microneedles, small-scale lancet-shaped devices that are commonly used for delivery of pharmacologic agents and vaccines, were made out of an acid anhydride copolymer using visible light dynamic mask micro-stereolithography/micromolding and loaded with miconazole using a piezoelectric inkjet printer. The miconazole-coated microneedles showed biodegradation and antifungal activity against the organism Candida albicans (ATCC 90028) on Sabouraud dextrose agar using an in vitro agar plating method. The results of this study demonstrate that piezoelectric inkjet printing may be used load microneedles and other drug delivery devices with pharmacologic agents. Miconazole-loaded microneedles prepared by the visible light dynamic mask micro-stereolithography-micromolding-piezoelectric inkjet printing approach have potential use in transdermal treatment of cutaneous fungal infections.