Human CARD9: A Critical Molecule of Fungal Immune Surveillance.
Human CARD9: A Critical Molecule of Fungal Immune Surveillance.
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DOI：
10.3389/fimmu.2018.01836
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发表时间：
2018
影响因子：
7.3
通讯作者：
Lionakis MS
中科院分区：
文献类型：
--
作者：
Drummond RA;Franco LM;Lionakis MS
CARD9是一种信号转导衔接蛋白，其参与来自多种先天模式识别受体的信号转导，包括C型凝集素受体和细胞内NOD受体和核酸传感器。因此，CARD9已在动物模型中显示为对细菌、真菌和病毒的免疫的重要调节剂。在患有常染色体隐性CARD9缺陷的人类中的研究表明，该分子在中枢神经系统、口腔粘膜和皮肤中的抗真菌免疫应答的激活中具有高度特异性的作用。此外，CARD9依赖性功能最近已被指示调节自身免疫、炎性肠病和癌症的发展。在这篇简短的综述中，我们重点介绍了最近的研究，这些研究已经确定了CARD9在各种疾病背景下的几种新功能，我们总结了当代对人类CARD9缺陷的遗传学和免疫学的理解。
CARD9 is a signaling adaptor protein that is involved in the transduction of signals from a variety of innate pattern recognition receptors, including the C-type lectin receptors and intracellular NOD receptors and nucleic acid sensors. As a result, CARD9 has been shown in animal models to be an important regulator of immunity to bacteria, fungi, and viruses. Studies in humans with autosomal recessive CARD9 deficiency have indicated a highly specific role for this molecule in the activation of antifungal immune responses in the central nervous system, the oral mucosa, and the skin. Moreover, CARD9-dependent functions have recently been indicated to modulate the development of autoimmunity, inflammatory bowel diseases, and cancer. In this mini-review, we highlight the recent studies that have identified several novel functions of CARD9 in various disease contexts, and we summarize the contemporary understanding of the genetics and immunology of human CARD9 deficiency.
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对C型凝集素受体/Card9信号在人类抗真菌免疫中的作用的机械洞察力。
影响因子：
5.7
作者：
Drummond RA;Lionakis MS
通讯作者：
Lionakis MS
DOI：
10.1056/nejmoa1208487
发表时间：
2013-10-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lanternier F;Pathan S;Vincent QB;Liu L;Cypowyj S;Prando C;Migaud M;Taibi L;Ammar-Khodja A;Stambouli OB;Guellil B;Jacobs F;Goffard JC;Schepers K;Del Marmol V;Boussofara L;Denguezli M;Larif M;Bachelez H;Michel L;Lefranc G;Hay R;Jouvion G;Chretien F;Fraitag S;Bougnoux ME;Boudia M;Abel L;Lortholary O;Casanova JL;Picard C;Grimbacher B;Puel A
通讯作者：
Puel A
IgA肾病的新风险基因座的发现暗示了与肠道病原体免疫有关的基因。
影响因子：
30.8
作者：
Kiryluk, Krzysztof;Li, Yifu;Scolari, Francesco;Sanna-Cherchi, Simone;Choi, Murim;Verbitsky, Miguel;Fasel, David;Lata, Sneh;Prakash, Sindhuri;Shapiro, Samantha;Fischman, Clara;Snyder, Holly J.;Appel, Gerald;Izzi, Claudia;Viola, Battista Fabio;Dallera, Nadia;Del Vecchio, Lucia;Barlassina, Cristina;Salvi, Erika;Bertinetto, Francesca Eleonora;Amoroso, Antonio;Savoldi, Silvana;Rocchietti, Marcella;Amore, Alessandro;Peruzzi, Licia;Coppo, Rosanna;Salvadori, Maurizio;Ravani, Pietro;Magistroni, Riccardo;Ghiggeri, Gian Marco;Caridi, Gianluca;Bodria, Monica;Lugani, Francesca;Allegri, Landino;Delsante, Marco;Maiorana, Mariarosa;Magnano, Andrea;Frasca, Giovanni;Boer, Emanuela;Boscutti, Giuliano;Ponticelli, Claudio;Mignani, Renzo;Marcantoni, Carmelita;Di Landro, Domenico;Santoro, Domenico;Pani, Antonello;Polci, Rosaria;Feriozzi, Sandro;Chicca, Silvana;Galliani, Marco;Gigante, Maddalena;Gesualdo, Loreto;Zamboli, Pasquale;Battaglia, Giovanni Giorgio;Garozzo, Maurizio;Maixnerova, Dita;Tesar, Vladimir;Eitner, Frank;Rauen, Thomas;Floege, Juergen;Kovacs, Tibor;Nagy, Judit;Mucha, Krzysztof;Paczek, Leszek;Zaniew, Marcin;Mizerska-Wasiak, Malgorzata;Roszkowska-Blaim, Maria;Pawlaczyk, Krzysztof;Gale, Daniel;Barratt, Jonathan;Thibaudin, Lise;Berthoux, Francois;Canaud, Guillaume;Boland, Anne;Metzger, Marie;Panzer, Ulf;Suzuki, Hitoshi;Goto, Shin;Narita, Ichiei;Caliskan, Yasar;Xie, Jingyuan;Hou, Ping;Chen, Nan;Zhang, Hong;Wyatt, Robert J.;Novak, Jan;Julian, Bruce A.;Feehally, John;Stengel, Benedicte;Cusi, Daniele;Lifton, Richard P.;Gharavi, Ali G.
通讯作者：
Gharavi, Ali G.
影响因子：
6.7
作者：
Jhingran A;Kasahara S;Shepardson KM;Junecko BA;Heung LJ;Kumasaka DK;Knoblaugh SE;Lin X;Kazmierczak BI;Reinhart TA;Cramer RA;Hohl TM
通讯作者：
Hohl TM
影响因子：
4.5
作者：
Beaudoin M;Goyette P;Boucher G;Lo KS;Rivas MA;Stevens C;Alikashani A;Ladouceur M;Ellinghaus D;Törkvist L;Goel G;Lagacé C;Annese V;Bitton A;Begun J;Brant SR;Bresso F;Cho JH;Duerr RH;Halfvarson J;McGovern DP;Radford-Smith G;Schreiber S;Schumm PL;Sharma Y;Silverberg MS;Weersma RK;Quebec IBD Genetics Consortium;NIDDK IBD Genetics Consortium;International IBD Genetics Consortium;D'Amato M;Vermeire S;Franke A;Lettre G;Xavier RJ;Daly MJ;Rioux JD
通讯作者：
Rioux JD