Role of serotonergic and noradrenergic systems in a model of visceral pain.
Role of serotonergic and noradrenergic systems in a model of visceral pain.
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血清素能和去甲肾上腺素能系统在内脏疼痛模型中的作用。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
A. Płażnik
中科院分区：
文献类型：
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作者：
I. Korzeniewska;A. Płażnik
在内脏痛大鼠模型上，观察了选择性调节5-羟色胺能和去甲肾上腺素能系统活动的效果。结果发现，对氯苯丙氨酸(p-CPA)和N-chloro-ethyl-2，2--bromo-benzylamine(DSP-4)-induced对大鼠内脏痛觉均无明显影响，脑和脊髓5-羟色胺和去甲肾上腺素的选择性耗竭对痛觉无明显影响。另一方面，全选择性5-HT1a受体激动剂8-OH-DPAT、α1受体拮抗剂哌唑嗪、α2受体激动剂可乐定和两种β受体拮抗剂心得安和美托洛尔均能剂量依赖性地减少2%醋酸溶液引起的小鼠扭体次数(扭体实验)。用选择性受体配体DSP-4和p-CPA的结果表明，中枢神经系统的去甲肾上腺素能和5-羟色胺能神经支配对动物扭体行为的影响是复杂的。在这种内脏痛模型中，5-HT1a受体和α2-肾上腺素受体在大鼠行为表达中起抑制作用。另一方面，肾上腺素能α1和β1受体促进刺激剂的行为效应。
The effects of selective manipulations of activity of the serotonergic and noradrenergic systems were examined in the rat model of visceral pain. It was found that neither p-chlorophenylalanine(p-CPA)- nor N-chloro-ethyl-2,2--bromo-benzylamine(DSP-4)-induced strong and selective depletion of the brain and spinal cord serotonin and noradrenaline, respectively, changed in a significant way rat visceral pain perception. On the other hand, 8-OH-DPAT, a full selective 5-HT1A receptor agonist, prazosin, an alpha1-adrenoceptor antagonist, clonidine, an alpha2-adrenoceptor agonist, and two beta-adrenoceptor antagonists: propranolol and metoprolol, dose-dependently reduced the number of body writhes induced by intraperitoneally administered 2% solution of acetic acid (the writhing test). The results obtained with selective receptor ligands, DSP-4 and p-CPA, indicate that the noradrenergic and serotonergic innervation of the central nervous system contribute in a complex way to the animal behavior in the writhing test. The 5-HT1A receptors and alpha2-adrenoceptors play an inhibitory role in the expression of rat behavior in this model of visceral pain. On the other hand, adrenergic alpha1 and beta1 receptors facilitate the behavioral effects of the irritant agent.