Use of transcriptomics in understanding mechanisms of drug-induced toxicity.
Use of transcriptomics in understanding mechanisms of drug-induced toxicity.
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DOI：
10.2217/pgs.10.37
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发表时间：
2010-04
期刊：
影响因子：
2.1
通讯作者：
Paules RS
中科院分区：
文献类型：
--
作者：
Cui Y;Paules RS
药物不良反应（ADR）是一个重要的临床问题和严重的公共卫生风险。了解潜在的机制对于不同ADR的临床诊断和管理至关重要。毒理基因组学可以揭示对生物学途径和过程的影响，这些生物学途径和过程以前未被认为参与药物反应。机制假设可以产生，然后可以使用药理学，毒理学，分子生物学和遗传学的全部武器库进行实验测试。最近的药物诱导的毒性，这提供了宝贵的机制的见解各种ADR的转录组学研究，已审查重点肾毒性和肝毒性。相关的问题进行了讨论，包括外推的机制研究结果从实验模型系统到人类使用血液作为器官损伤的替代组织和比较系统生物学方法。
Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk. Understanding the underlying mechanisms is critical for clinical diagnosis and management of different ADRs. Toxicogenomics can reveal impacts on biological pathways and processes that had not previously been considered to be involved in a drug response. Mechanistic hypotheses can be generated that can then be experimentally tested using the full arsenal of pharmacology, toxicology, molecular biology and genetics. Recent transcriptomic studies on drug-induced toxicity, which have provided valuable mechanistic insights into various ADRs, have been reviewed with a focus on nephrotoxicity and hepatotoxicity. Related issues have been discussed, including extrapolation of mechanistic findings from experimental model systems to humans using blood as a surrogate tissue for organ damage and comparative systems biology approaches.
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影响因子：
3.8
作者：
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通讯作者：
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影响因子：
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