A sensor for acetaminophen in a blood medium using a Cu(II)-conducting polymer complex modified electrode
A sensor for acetaminophen in a blood medium using a Cu(II)-conducting polymer complex modified electrode
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DOI：
10.1016/j.aca.2004.03.005
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发表时间：
2004-06-11
影响因子：
6.2
通讯作者：
Shim, YB
中科院分区：
文献类型：
--
作者：
Boopathi, M;Won, MS;Shim, YB
络合铜离子在三噻吩羧酸（TTCA）聚合物膜导致增强的阳极电流对乙酰氨基酚氧化相比，聚合物涂层和裸玻碳电极在人体血液和缓冲介质。扫描电子显微镜（SEM）和ESCA实验表明，铜的参与对乙酰氨基酚的电催化氧化。没有观察到其他生物学上重要的和酚类化合物与这种修饰电极的干扰。特别是，N-乙酰半胱氨酸，对乙酰氨基酚中毒的解毒剂的非干扰，揭示了所提出的方法在医学应用中的优越性。此外，本发明的改性电极避免了在较高浓度的对乙酰氨基酚下的表面结垢。用CV获得的校准范围基于2.0 x 10（-5）至5.0 x 10（-3）M [r（2）= 0.997（n = 5，R.S.D. = 2.5%）; DL = 5.0 × 10（-6）M（S/N = 3）]。该修饰电极在不经预处理的情况下，用循环伏安法和安培法测定了不同药物中对乙酰氨基酚的含量。(C)2004 Elsevier B. V.保留所有权利。
Complexation of Cu ions in a terthiophene carboxylic acid (TTCA) polymer film resulted an enhanced anodic current for acetaminophen oxidation when compared to polymer coated and bare glassy carbon electrodes in human blood and buffer media. Scanning electron microscopy (SEM) and ESCA experiments indicate the involvement of copper in the electrocatalytic oxidation of acetaminophen. No interference was observed from other biologically important and phenolic compounds used with this modified electrode. Especially, the non-interference from N-acetylcysteine, an antidote for the treatment of acetaminophen poisoning, reveals the proposed method's superiority in medicinal applications. In addition, the present modified electrode avoids surface fouling at higher concentrations of acetaminophen. The calibration range obtained with CV was based between 2.0 x 10(-5) and 5.0 x 10(-3) M [r(2) = 0.997 (n = 5, R.S.D. = 2.5%); DL = 5.0 x 10(-6) M (S/N = 3)]. The analytical utility of the modified electrode was achieved by analyzing the content of acetaminophen in different drugs without pretreatment using CV and amperometric techniques. (C) 2004 Elsevier B.V. All rights reserved.