Polyunsaturated Fatty Acids Are Associated With Behavior But Not With Cognition in Children With and Without ADHD: An Italian study
Polyunsaturated Fatty Acids Are Associated With Behavior But Not With Cognition in Children With and Without ADHD: An Italian study
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DOI：
10.1177/1087054716629215
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发表时间：
2018-08-01
影响因子：
3
通讯作者：
Nobile, Maria
中科院分区：
文献类型：
--
作者：
Crippa, Alessandro;Agostoni, Carlo;Nobile, Maria
目的：本研究旨在探讨学龄期注意缺陷多动障碍儿童多不饱和脂肪酸（PUFAs）水平与其认知和行为特征的关系。方法：在干预试验（clinicaltrials.gov NCT 01796262）的基线时，对73名患有和不患有ADHD的儿童进行了认知任务和行为评定量表的评估，包括生活质量和整体功能。认知任务/行为评分与血液PUFA水平之间进行相关性分析。结果：ADHD儿童的DHA、omega-3指数和总PUFA水平较低。PUFA与行为呈正相关，但与认知领域并不一致。结论：本研究证实，ADHD儿童在意大利环境中显示异常脂肪酸谱。此外，PUFA与行为有关，但与认知无关。因此，血液中PUFA水平较低不仅与ADHD症状有关，而且与生活质量较差有关。
Objective: This study aimed to investigate the relationship between polyunsaturated fatty acids (PUFAs) status, cognitive, and behavioral traits of ADHD in school-aged children. Method: Seventy-three children with and without ADHD were assessed with cognitive tasks and behavioral rating scales including quality of life and global functioning at baseline of an intervention trial (clinicaltrials.gov NCT01796262). Correlation analyses were performed between the cognitive tasks/behavioral ratings and blood PUFA levels. Results: Children with ADHD had lower levels of DHA, omega-3 index, and total PUFA. PUFAs were positively associated with behavior but not consistently related to cognitive domains. Conclusion: The present study confirms that children with ADHD display abnormal fatty acid profiles within an Italian setting. Furthermore, PUFAs were associated with behavior but not with cognition. Accordingly, for the first time, lower blood levels of PUFA were associated not only with symptoms of ADHD but also with a poorer quality of life.