RETICULAR MESHWORK OF THE SPLEEN IN RATS STUDIED BY ELECTRON-MICROSCOPY
RETICULAR MESHWORK OF THE SPLEEN IN RATS STUDIED BY ELECTRON-MICROSCOPY
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DOI：
10.1002/aja.1001810303
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发表时间：
1988-03-01
影响因子：
--
通讯作者：
NAMIHISA, T
中科院分区：
文献类型：
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作者：
SAITO, H;YOKOI, Y;NAMIHISA, T
通过透射电子显微镜研究了由纤维网和细胞网组成的大鼠脾的网状网络。脾髓纤维网由网状纤维和窦基底膜组成。这些网状纤维和基底膜彼此连续。网状纤维被网状细胞包裹，由两个基本元素组成：（1）网状细胞的外周基底层，和（2）中央结缔组织空间，其中存在微原纤维、胶原原纤维、弹性纤维和无髓鞘肾上腺素能神经纤维。鼻窦的基底膜夹在网状细胞和鼻窦内皮细胞之间，由致密层样材料、微原纤维、胶原原纤维和弹性纤维组成。这些结缔组织纤维成分的存在表明这些基底膜中存在结缔组织空间。基底膜分为三部分：网状细胞基底层、结缔组织间隙和窦内皮细胞基底层。当结缔组织间隙非常小或不存在时，两个基底层可能融合形成脾窦壁的单一厚基底膜。具有这些结构的纤维网负责支撑（胶原原纤维）和反弹（弹性纤维）。细胞网状细胞及其细胞质突起被认为是肌成纤维细胞，其具有丰富的收缩性微丝、致密体、半桥粒、基底层和发育良好、表面粗糙的内质网和高尔基复合体，这些都是成纤维细胞和平滑肌细胞的特征。它们可能在脾收缩和纤维网纤维发生中发挥作用。收缩能力可能受到穿过网状纤维的无髓鞘肾上腺素能神经纤维的影响。脾脏的三维网状网由支撑纤维网和收缩性肌纤维母细胞网组成。这种网状结构不仅支持器官，而且还与囊-小梁系统中的主要收缩元件协作，有助于循环调节中的收缩机制。
The reticular meshwork of the rat spleen, which consists of both fibrous and cellular reticula, was investigated by transmission electron microscopy. The fibrous reticulum of the splenic pulp is composed of reticular fibers and basement membranes of the sinuses. These reticular fibers and basement membranes are continuous with each other. The reticular fibers are enfolded by reticular cells and are composed of two basic elements: (1) peripheral basal laminae of the reticular cells, and (2) central connective tissue spaces in which microfibrils, collagenous fibrils, elastic fibers, and unmyelinated adrenergic nerve fibers are present. The basement membranes of the sinuses are sandwiched between reticular cells and sinus endothelial cells and are composed of lamina-densalike material, microfibrils, collagenous fibrils, and elastic fibers. The presence of these connective tissue fibrous components indicates that there are connective tissue spaces in these basement membranes. The basement membrane is divided into three parts: the basal lamina of the reticular cell, the connective tissue space, and the basal lamina of the sinus endothelial cell. When the connective tissue space is very small or absent, the two basal laminae may fuse to form a single, thick basement membrane of the splenic sinus wall. The fibrous reticulum having these structures is responsible for support (collagenous fibrils) and rebounding (elastic fibers). The cells of the cellular reticulum.sbd.reticular cells and their cytoplasmic processes, which possess abundant contractile microfilaments, dense bodies, hemidesmosomes, basal laminae, and a well-developed, rough-surfaced endoplasmic reticulum, and Golgi complexes, which are characteristic of both fibroblasts and smooth muscle cells.sbd.are considered to be myofibroblasts. They may play roles in splenic contraction and in fibrogenesis of the fibrous reticulum. The contractile ability may be influenced by the unmyelinated adrenergic nerve fibers that pass through the reticular fibers. The three-dimensional reticular meshwork of the spleen consists of sustentacular fibrous reticulum and contractile myofibroblastic cellular reticulum. This meshwork not only supports the organ but also contributes to a contractile mechanism in circulation regulation, in collaboration with major contractile elements in the capsulo-trabecular system.