HI and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes
HI and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes
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DOI：
10.1016/j.virol.2004.04.040
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发表时间：
2004-08-01
期刊：
影响因子：
3.7
通讯作者：
Skehel, JJ
中科院分区：
文献类型：
--
作者：
Russell, RJ;Gamblin, SJ;Skehel, JJ
比较H3，H5和H9亚型血凝素的结构，我们推断出包括所有15种流感亚型在四个分支的结构基础。H3、H5和H9代表这些进化枝中的三个;我们现在报告H7 HA的结构作为第四进化枝的代表。我们确认了HA 2保守的中央α-螺旋的N-末端的转弯结构，以及作为进化枝特异性特征的“融合肽”附近的可电离残基的组合。我们比较了三个H1 HA与H5 HA在同一分支的结构，以完善我们以前的分类，我们确认的分支分为两组的两个。我们还显示了碳水化合物侧链在形成分支特异性结构标记的酯酶融合结构域边界中的作用。(C)2004年爱思唯尔公司All rights reserved.
Comparing the structures of H3, H5 and H9 subtype haemagglutinins, we deduced a structural basis for including all 15 influenza subtypes in four clades. H3, H5 and H9 represent three of these clades; we now report the structure of an H7 HA as a representative of the fourth clade. We confirm the structure of the turn at the N-terminus of the conserved central alpha-helix of HA2, and the combination of ionisable residues near the "fusion peptide" as clade-specific features. We compare the structures of three H1 HAs with H5 HA in the same clade, to refine our previous classification and we confirm the division of the clades into two groups of two. We also show the roles of carbohydrate side chains in the esterase-fusion domain boundaries in the formation of clade-specific structural markers. (C) 2004 Elsevier Inc. All rights reserved.