Maspin: a tumor suppressing serpin.
Maspin: a tumor suppressing serpin.
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DOI：
10.1007/978-3-642-61107-0_4
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发表时间：
1996
影响因子：
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通讯作者：
Ruth Sager;Shijie Sheng;P. Pemberton;M. J. Hendrix
中科院分区：
文献类型：
--
作者：
Ruth Sager;Shijie Sheng;P. Pemberton;M. J. Hendrix
Maspin（乳腺丝氨酸蛋白酶抑制剂）是丝氨酸蛋白酶抑制剂超家族的成员（Potempaet al. 1994）。该基因首先根据其在正常乳腺上皮细胞中而非肿瘤来源的乳腺上皮细胞中的 mRNA 水平表达，通过消减杂交来鉴定（Zouet al. 1994）。克隆并测序的 cDNA 由 2584 个核苷酸组成，编码具有丝氨酸蛋白酶抑制剂总体结构的 42 kDa 肽。 Maspin 定位于染色体 18q21.3-q23 (Sageret al. 1994)，与纤溶酶原激活剂抑制剂 2 (PAI-2)、BCL2、候选肿瘤抑制基因 DCC (Sageret al. 1994) 和候选肿瘤抑制基因 SCCA (Schneideret al. 1995) 密切相关。
Maspin (mammary serpin) is a member of the serpin superfamily (Potempaet al. 1994). The gene was first identified by subtractive hybridization on the basis of its expression at the mRNA level in normal but not in tumor-derived mammary epithelial cells (Zouet al. 1994). The cloned and sequenced cDNA consists of 2584 nucleotides encoding a 42 kDa peptide with the overall structure of a serpin. Maspin has been localized to chromosome 18q21.3-q23 (Sageret al. 1994) closely linked to plasminogen activator inhibitor-2 (PAI-2), to BCL2, to the candidate tumor suppressor gene DCC (Sageret al. 1994), and to the candidate tumor suppressor gene SCCA (Schneideret al. 1995).