MT4-MMP: The GPI-Anchored Membrane-Type Matrix Metalloprotease with Multiple Functions in Diseases
MT4-MMP: The GPI-Anchored Membrane-Type Matrix Metalloprotease with Multiple Functions in Diseases
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DOI：
10.3390/ijms20020354
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发表时间：
2019-01
影响因子：
5.6
通讯作者：
C. Yip;P. Foidart;A. Noël;N. Sounni
中科院分区：
文献类型：
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作者：
C. Yip;P. Foidart;A. Noël;N. Sounni
MT4-MMP（或 MMP17）属于膜型基质金属蛋白酶 (MT-MMP) 家族。该蛋白酶家族在多个生理过程中有助于细胞外基质重塑，包括胚胎发生、器官发生、组织再生、血管生成、伤口愈合和炎症。 MT4-MMP（MMP17）与该家族的其他成员相比，在序列同源性、底物特异性和内化模式方面表现出独特的特征，表明其具有独特的生理和病理功能。虽然人们对 MT4-MMP 的生理功能知之甚少，但它参与了关节炎、心血管疾病和癌症进展等不同的病理过程。 mt4-mmp 转录本已在多种癌症中检测到。 MT4-MMP 对肿瘤发展的贡献已在胃癌、结肠癌、头颈癌以及乳腺癌中进行了更深入的研究。鉴于其对不同病理学，特别是癌症的贡献，MT4-MMP 代表了一个有趣的治疗靶点。在这篇综述中，我们研究了它的生物学和结构特性，并对其生理和病理功能提出了概述。
MT4-MMP (or MMP17) belongs to the Membrane-Type Matrix Metalloproteinase (MT-MMP) family. This family of proteases contributes to extracellular matrix remodeling during several physiological processes, including embryogenesis, organogenesis, tissue regeneration, angiogenesis, wound healing, and inflammation. MT4-MMP (MMP17) presents unique characteristics compared to other members of the family in terms of sequence homology, substrate specificity, and internalization mode, suggesting distinct physiological and pathological functions. While the physiological functions of MT4-MMP are poorly understood, it has been involved in different pathological processes such as arthritis, cardiovascular disease, and cancer progression. The mt4-mmp transcript has been detected in a large diversity of cancers. The contribution of MT4-MMP to tumor development has been further investigated in gastric cancer, colon cancer, head and neck cancer, and more deeply in breast cancer. Given its contribution to different pathologies, particularly cancers, MT4-MMP represents an interesting therapeutic target. In this review, we examine its biological and structural properties, and we propose an overview of its physiological and pathological functions.