Effect of the function of polymorphonuclear leukocytes and interleukin-1 beta on wound healing in patients with diabetic foot infections
Effect of the function of polymorphonuclear leukocytes and interleukin-1 beta on wound healing in patients with diabetic foot infections
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DOI：
10.1016/j.jinf.2006.05.004
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发表时间：
2007-03-01
影响因子：
28.2
通讯作者：
Cavuslu, S.
中科院分区：
文献类型：
--
作者：
Oncul, O.;Yildiz, S.;Cavuslu, S.
目的：本研究旨在前瞻性地探讨多形核白细胞（PMNL）吞噬活性指数（派）、细胞内杀伤活性（IKA）及白细胞介素-1 β（IL-1 β）水平对预后的影响IL-1 β对糖尿病足感染（DFI）患者预后的影响。在治疗开始时、治疗第2周和第4周分别检测PMNL中派、IKA和IL-1 β水平，结果：66例糖尿病患者（38例）和28例非糖尿病对照者（28例）被纳入研究。在23例HG患者中观察到完全恢复，而15例（NHG）患者对治疗无反应，9例患者最终截肢。在基线时，FIG中的派、IKA和IL-1 β水平与NHG中的那些相比没有显著差异，但在第2和第4周，派和IKA水平显著高于NHG中的那些，而IL-1 β水平显著低于NHG中的那些。另一方面，在基线时，与对照组相比，HG中的派和IKA值显著降低，而IL-1 β水平显著升高。结论：DFI患者PMNL功能和IL-1 β调节功能恶化，提示糖尿病治疗效果不佳。(C)2006年，英国传染病协会。由Elsevier Ltd.出版，保留所有权利。
Objectives: This study was carried out prospectively to determine the effect on prognosis of phagocytic activity index (PAI) and intracellular killing activity (IKA) of polymorphonuclear leukocytes (PMNL), and the levels of interleukin-1 beta (IL-1 beta) on prognosis in patients with diabetic foot infection (DFI).Methods: The evaluation of PAI and IKA in PMNL and the levels of IL-1 beta were performed at the beginning and in the second and fourth weeks of therapy in all diabetic patients, who were categorized into a heating group (HG) and a non-heating group (NHG) on the basis of therapy results.Results: Sixty-six cases (38 diabetic patients and 28 non-diabetic controls) were included in the study. Full recovery was observed in 23 HG patients, whereas 15 (NHG) patients were unresponsive to treatment and nine patients were subjected to amputation at the end. At the baseline, PAI, IKA and IL-1 beta levels in FIG were not significantly different compared to those of NHG, but at weeks 2 and 4, PAI and IKA levels were significantly higher and IL-1 beta levels were significantly lower than those in NHG. On the other hand, at the baseline, PAI and IKA values in HG were significantly lower and IL-1 beta levels were significantly higher in comparison with the controls. However, no significant difference was observed at week 2 or 4.Conclusion: Our results suggest that the PMNL functions and IL-1 beta regulation deteriorated in patients with DFI, and that such deteriorations might indicate inefficient therapeutic responses in patients with diabetes mellitus. (C) 2006 The British Infection Society. Published by Elsevier Ltd. ALL rights reserved.