Swainsonine inhibition of spontaneous metastasis.
Swainsonine inhibition of spontaneous metastasis.
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苦马豆素抑制自发转移。
DOI：
10.1093/jnci/81.13.1024
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Olden,K
中科院分区：
文献类型：
--
作者：
Newton,SA;White,SL;Humphries,MJ;Olden,K
我们之前已经证明，对 C57BL/6 小鼠全身给药八氢吲嗪二醇，通过涉及白细胞介素 2 产生和自然杀伤细胞活性增强的机制，抑制静脉注射的 B16F10 黑色素瘤细胞的肺转移。根据这一使用“实验性转移”模型系统的发现，我们考虑了：(a)苦马豆素是否能有效抑制真实或自发转移；(b)该药物是否也能抑制肺部以外器官的转移形成； (c)该药物是否会阻断不同组织学类型或来源的肿瘤细胞的转移。我们的数据表明，苦马豆素可分别有效抑制 B16-BL6 黑色素瘤（88%）和 M5076 网状肉瘤（95%）小鼠肿瘤细胞向肺和肝的自发转移。在这两种情况下，药物的抗转移活性随着饮用水中浓度的增加而增加，最高可达 3 µg/mL 这些研究结果表明，苦马豆素的抗转移活性不仅限于人工或实验诱导的转移，也不限于单一肿瘤类型或特定器官。转移的抑制可能是由于目前正在研究的一系列事件的结合。
We have previously shown that swainsonine, administered systemically to C57BL/6 mice, inhibited the pulmonary metastasis of iv injected B16F10 melanoma cells by a mechanism involving interleukin-2 production and augmentation of natural killer cell activity. From this finding, which uses an “experimental metastasis” model system, we considered:(a)whether swainsonine would be effective in the inhibition of authentic or spontaneous metastasis;(b)whether the drug would also inhibit metastasis formation in organs other than the lungs; and(c)whether the drug would block the metastasis of tumor cells of different histological type or origin. Our data indicated that swainsonlne effectively inhibited the spontaneous metastasis of B16-BL6 melanoma (by 88%) and M5076 reticulum sarcoma (by 95%) murine tumor cells to the lung and liver, respectively. In both cases, the antimetastatic activity of the drug increased as a function of the concentration in drinking water up to 3 µg/mL These findings indicate that the antimetastatic activity of swainsonine is not limited to artificial or experimentally induced metastasis nor to a single tumor type or specific organ. The inhibition of metastasis is likely due to a combination of events, which are currently under investigation.