IgG subclass responses in a longitudinal study of canine visceral leishmaniasis
IgG subclass responses in a longitudinal study of canine visceral leishmaniasis
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DOI：
10.1016/s0165-2427(02)00311-2
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发表时间：
2003-02-10
影响因子：
1.8
通讯作者：
Day, MJ
中科院分区：
文献类型：
--
作者：
Quinnell, RJ;Courtenay, O;Day, MJ
内脏利什曼病（VL）是由幼利什曼原虫引起的一种重要的家犬疾病。在这里，我们提供了一组自然感染的巴西狗对粗L婴儿抗原的IgG亚类抗体反应的数据。特异性IgG血清阳性的57只犬中，分别有98.8%、58.8%、70%和82%出现特异性IgG1-IgG4反应。所有IgG亚类的水平呈强相关性。所有IgG亚类的水平在血清转化时升高，几个月后达到平台期。病犬的所有IgG亚类水平均高于健康犬，除IgG2外，寄生虫阳性犬的所有IgG亚类水平（通过PCR）均高于寄生虫阴性犬。然而，与健康或寄生虫阴性感染的狗相比，患病或寄生虫阳性狗的IgG2水平相对于IgG1水平较低。与以往的研究相反，结果表明犬VL与所有IgG亚类特异性抗体上调有关，特别是IgG1， IgG3和IgG4。(C) 2002 Elsevier Science B.V.版权所有
Visceral leishmaniasis (VL), caused by Leishmania infantum, is an important disease of domestic dogs. Here, we present data on the IgG subclass antibody response to crude L infantum antigen in a cohort of naturally infected Brazilian dogs. Specific IgG1-IgG4 responses could be detected in 98, 58, 70 and 82%, respectively of 57 dogs that were seropositive for specific IgG. Levels of all IgG subclasses were strongly inter-correlated. Levels of all IgG subclasses increased at the time of seroconversion, before reaching a plateau after several months. Levels of all IgG subclasses were higher in sick dogs than healthy dogs, and levels of all except IgG2 were higher in parasite-positive (by PCR) than parasite-negative dogs. However, levels of IgG2 relative to IgG1 were lower in sick or parasite-positive dogs compared to healthy or parasite-negative infected dogs. In contrast to previous studies, the results suggest that canine VL is associated with upregulation of specific antibody of all IgG subclasses, particularly IgG1, IgG3 and IgG4. (C) 2002 Elsevier Science B.V. All rights reserved.