Wnt and calcium signaling:: β-Catenin-independent pathways
Wnt and calcium signaling:: β-Catenin-independent pathways
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DOI：
10.1016/j.ceca.2005.06.022
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发表时间：
2005-09-01
期刊：
影响因子：
4
通讯作者：
Moon, RT
中科院分区：
文献类型：
--
作者：
Kohn, AD;Moon, RT
Wnt信号传导是一个复杂的通路，其中β-连环蛋白通常被视为中心介导物。然而.在过去的15年中，已经提出了至少三种Wnt介导的途径，其功能独立于β-连环蛋白。一种途径涉及钙/钙调蛋白依赖性激酶II（CamKII）和蛋白激酶C（PKC）的活化。另一种包括募集异源三聚体GTP结合蛋白以激活磷脂酶C（PLC）和磷酸二酯酶（PDE）。最后，一个途径类似的平面细胞极性（PCP）途径在果蝇已被确定，激活Jun-N-末端激酶（JNK），也许，小GTP结合蛋白。钙在所有这些途径中都被认为是重要的第二信使。这篇综述将集中于钙在Wnt信号传导中的作用，因此，对β-连环蛋白非依赖性Wnt信号传导提供了有限的概述。(C)2005爱思唯尔有限公司保留所有权利。
Wnt signaling is a complex pathway in which beta-catenin is typically viewed as a central mediator. However. within the past 15 years, at least three Wnt-mediated pathways have been proposed that function independent of beta-catenin. One pathway involves activation of calcium/calmodulin-dependent kinase II (CamKII) and protein kinase C (PKC). Another includes recruitment of heterotrimeric GTP-binding proteins to activate phospholipase C (PLC) and phosphodiesterase (PDE). Lastly, a pathway similar to the planar cell polarity (PCP) pathway in Drosophila has been identified that activates the Jun-N-terminal kinase (JNK) and, perhaps, small GTP-binding proteins. Calcium has been implicated as an important second messenger in all of these pathways. This review will focus on the role of calcium in Wnt signaling and, as a consequence, provide a limited overview of beta-catenin-independent Wnt signaling. (C) 2005 Elsevier Ltd. All rights reserved.