Effects of minoxidil on ischemia-induced mechanical and metabolic dysfunction in dog myocardium.
Effects of minoxidil on ischemia-induced mechanical and metabolic dysfunction in dog myocardium.
复制标题
米诺地尔对缺血引起的狗心肌机械和代谢功能障碍的影响。
DOI：
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
K. Ichihara
中科院分区：
文献类型：
--
作者：
A. Yamamoto;K. Satoh;Kenichi Ichinosawa;S. Kaneta;S. Kano;K. Ichihara
在麻醉开胸犬上观察了米诺地尔对缺血性心肌机械和代谢功能障碍的影响。结扎左冠状动脉前降支，使左心室局部缺血20分钟，然后再灌注120分钟。结扎前10分钟静脉注射二甲亚砜或米诺地尔（0.3或1.0 mg/kg）。缺血可使局部心肌收缩减弱，再灌注可使局部心肌收缩恢复，但不能完全恢复。缺血时心肌代谢紊乱，如心肌ATP和磷酸肌酸水平降低。这些由缺血引起的代谢变化可通过再灌注恢复。米诺地尔注射液在0.3和1.0毫克/公斤显着降低血压，但增加冠状动脉流量。米诺地尔预处理可明显促进缺血再灌注心肌收缩功能的恢复。米诺地尔0.3 mg/kg可显著保护缺血心肌ATP和磷酸肌酸水平。米诺地尔对再灌注120 min心肌代谢无明显影响。总之，米诺地尔改善了再灌注心脏的机械功能障碍，低剂量的药物在缺血期间保留了高能磷酸盐。
Effects of minoxidil on ischemia-induced myocardial mechanical and metabolic dysfunction were examined in anesthetized open-chest dogs. A regional portion of the left ventricle was made ischemic for 20 min by ligating the left anterior descending coronary artery, and then reperfused for 120 min. Dimethylsulfoxide or minoxidil (0.3, or 1.0 mg/kg) was injected intravenously 10 min before ligation. Ischemia decreased regional myocardial contraction, and reperfusion recovered it but incompletely. Myocardial metabolic derangement was observed during ischemia, such as decreases in the myocardial levels of ATP and creatine phosphate. These metabolic changes caused by ischemia were restored by reperfusion. Minoxidil injection at 0.3 and 1.0 mg/kg significantly decreased blood pressures but increased coronary flow. Pretreatment with minoxidil significantly enhanced the recovery of myocardial contraction during reperfusion after ischemia. The levels of ATP and creatine phosphate in the ischemic myocardium were significantly preserved by minoxidil at 0.3 mg/kg. No significant effect of minoxidil on the metabolism was observed in the 120 min reperfused myocardium. In conclusion, minoxidil improved the mechanical dysfunction in the reperfused heart and the drug at low dose preserved high-energy phosphates during ischemia.
DOI：
10.1056/nejm198606263142604
发表时间：
1986-06
期刊：
The New England journal of medicine
影响因子：
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作者：
J. Cheung;J. Bonventre;C. Malis;A. Leaf
通讯作者：
J. Cheung;J. Bonventre;C. Malis;A. Leaf