Human preleukemia.
Human preleukemia.
复制标题
人类白血病前期。
DOI：
10.7326/0003-4819-93-2-347
复制
发表时间：
1980
影响因子：
39.2
通讯作者：
W. Golde
中科院分区：
文献类型：
--
作者：
Human Preleukemia;H. Phillip;Koeffler;David;W. Golde
白血病前期是指在急性髓细胞性白血病的典型特征发展之前，在一些患者中观察到的造血功能障碍综合征。临床上，白血病前期的特征是不同程度的全血细胞减少，伴随循环血液元素减少引起的相关症状。骨髓通常是细胞过多的，红系前体细胞有明显的形态异常，巨核细胞和粒细胞祖细胞有更细微的变化。在白血病过程的这一阶段，肿瘤克隆通常已经建立并占优势。应明确区分白血病前期综合征和易发生急性髓细胞性白血病的疾病。白血病前期与急性髓细胞性白血病一样，是一种克隆性造血干细胞肿瘤，在功能上表现为造血细胞成熟异常和无效造血。在白血病前期的过程中，前体细胞的成熟逐渐受损，并以急性髓性白血病的严重成熟阻滞为特征而终止。我们倾向于认为白血病前期是急性髓细胞性白血病的早期阶段。
Preleukemia refers to the syndrome of hematopoietic dysfunction seen in some patients before typical features of acute myelogenous leukemia develop. Clinically, preleukemia is characterized by variable degrees of pancytopenia, with associated symptoms due to decreased circulating blood elements. The bone marrow is usually hypercellular, and there are prominent morphologic abnormalities in erythroid precursors and more subtle changes in megakaryocytes and granulocyte progenitors. During this phase of the leukemic process, the neoplastic clone is usually already established and predominant. A clear distinction should be made between the preleukemic syndrome and diseases that predispose to development of acute myelogenous leukemia. Preleukemia, like acute myelogenous leukemia, is a clonal hematopoietic stem cell neoplasm manifested functionally by abnormal hematopoietic cell maturation and ineffective hematopoiesis. During the course of preleukemia, precursor cell maturation becomes progressively impaired with termination in the severe maturational block characteristic of acute myelogenous leukemia. We favor the concept that preleukemia is an early phase of acute myelogenous leukemia.