The integrin-mediated adhesive complex in the ancestor of animals, fungi, and amoebae
The integrin-mediated adhesive complex in the ancestor of animals, fungi, and amoebae
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DOI：
10.1016/j.cub.2021.04.076
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发表时间：
2021-05
期刊：
影响因子：
9.2
通讯作者：
Seungho Kang;Alexander K. Tice;Courtney W. Stairs;Robert E Jones;D. Lahr;Matthew W. Brown
中科院分区：
文献类型：
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作者：
Seungho Kang;Alexander K. Tice;Courtney W. Stairs;Robert E Jones;D. Lahr;Matthew W. Brown
整合素是跨膜受体，其在细胞外基质结合时激活信号转导途径。整合素介导的粘附复合物（IMAC）介导多种细胞生理过程。虽然IMAC被认为是动物特有的，但在过去的十年中，这些复合物在Obazoa的其他谱系中被发现，该群体包含动物，真菌和几种微生物真核生物。最近，许多来自变形虫（Amoebozoa）（Obazoa的真核生物超类群姐妹）、其他obazoans、孤儿原生生物谱系和真核生物最接近的原核亲戚的基因组和转录组已经可用。为了提高IMAC蛋白存在和出现的位置和时间的分辨率，我们调查了这些新获得的基因组和转录组中IMAC蛋白的存在。我们的研究结果强调，这些蛋白质中的许多蛋白质似乎在真核生物进化中比以前认为的更早地进化，这种显然古老的蛋白质复合物的共同选择是动物型多细胞生物出现的关键。IMAC在变形虫中的作用尚不清楚，但它们在至少一些单细胞生物中起着关键的粘附作用。
Integrins are transmembrane receptors that activate signal transduction pathways upon extracellular matrix binding. The integrin-mediated adhesive complex (IMAC) mediates various cell physiological processes. Although the IMAC was thought to be specific to animals, in the past ten years these complexes were discovered in other lineages of Obazoa, the group containing animals, fungi, and several microbial eukaryotes. Very recently, many genomes and transcriptomes from Amoebozoa (the eukaryotic supergroup sister to Obazoa), other obazoans, orphan protist lineages, and the eukaryotes' closest prokaryotic relatives, have become available. To increase the resolution of where and when IMAC proteins exist and have emerged, we surveyed these newly available genomes and transcriptomes for the presence of IMAC proteins. Our results highlight that many of these proteins appear to have evolved earlier in eukaryote evolution than previously thought and that co-option of this apparently ancient protein complex was key to the emergence of animal-type multicellularity. The role of the IMACs in amoebozoans is unknown, but they play critical adhesive roles in at least some unicellular organisms.